P05181.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Cytochrome P450 2E1
NCBI Official Synonym Full Names
cytochrome P450, family 2, subfamily E, polypeptide 1
NCBI Protein Information
cytochrome P450 2E1; CYPIIE1; cytochrome P450-J; microsomal monooxygenase; xenobiotic monooxygenase; 4-nitrophenol 2-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
UniProt Protein Name
Cytochrome P450 2E1
UniProt Synonym Protein Names
4-nitrophenol 2-hydroxylase (EC:1.14.13.n7); CYPIIE1; Cytochrome P450-JCytochrome P450 2E1, N-terminally processed
UniProt Synonym Gene Names
UniProt Entry Name
CP2E1_HUMAN
NCBI Summary for CYP2E1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
UniProt Comments for CYP2E1
CYP2E1: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms. Belongs to the cytochrome P450 family.
Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.14.13.n7; Lipid Metabolism - arachidonic acid; Oxidoreductase; Endoplasmic reticulum; Mitochondrial; Lipid Metabolism - linoleic acid
Chromosomal Location of Human Ortholog: 10q26.3
Cellular Component: intrinsic to endoplasmic reticulum membrane; Golgi membrane; endoplasmic reticulum membrane; intracellular membrane-bound organelle; mitochondrion; cytoplasm
Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; enzyme binding; iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; arachidonic acid epoxygenase activity; oxidoreductase activity; steroid hydroxylase activity; oxygen binding; monooxygenase activity
Biological Process: steroid metabolic process; triacylglycerol metabolic process; response to ethanol; xenobiotic metabolic process; response to ozone; exogenous drug catabolic process; monoterpenoid metabolic process; epoxygenase P450 pathway; heterocycle metabolic process; drug metabolic process; response to organic nitrogen
Research Articles on CYP2E1
Precautions
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Products associated with anti-CYP2E1 antibody
Pathways associated with anti-CYP2E1 antibody
Diseases associated with anti-CYP2E1 antibody
Organs/Tissues associated with anti-CYP2E1 antibody
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