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anti-DAGLA antibody :: Goat DAGLA Polyclonal Antibody

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Catalog # MBS422238
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

DAGLA, Polyclonal Antibody

Full Product Name

Goat anti-DAGLA Antibody

Product Synonym Names
DAGLA; diacylglycerol lipase, alpha; C11orf11; DAGL(ALPHA); DAGLALPHA; NSDDR; diacylglycerol lipase alpha; neural stem cell-derived dendrite regulator; KIAA0659; DAGLA antibody; diacylglycerol lipase; alpha antibody; C11orf11 antibody; DAGL(ALPHA) antibody; DAGLALPHA antibody; NSDDR antibody; diacylglycerol lipase alpha antibody; neural stem cell-derived dendrite regulator antibody; KIAA0659 antibody
Antibody/Peptide Pairs
DAGLA peptide (MBS425803) is used for blocking the activity of DAGLA antibody (MBS422238)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
PAKQDELVIS AR
OMIM
608687
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-PAKQDELVISAR, from the C Terminus of the protein sequence according to NP_006124.1.
Epitope
C Terminus
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-DAGLA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DAGLA antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-DAGLA antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.

Western Blot (WB) of anti-DAGLA antibody
(0.3ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-DAGLA antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for DAGLA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
114,952 Da
NCBI Official Full Name
sn1-specific diacylglycerol lipase alpha
NCBI Official Synonym Full Names
diacylglycerol lipase alpha
NCBI Official Symbol
DAGLA  [Similar Products]
NCBI Official Synonym Symbols
NSDDR; C11orf11; DAGLALPHA; DAGL(ALPHA)
  [Similar Products]
NCBI Protein Information
sn1-specific diacylglycerol lipase alpha
UniProt Protein Name
Sn1-specific diacylglycerol lipase alpha
UniProt Synonym Protein Names
Neural stem cell-derived dendrite regulator
UniProt Gene Name
DAGLA  [Similar Products]
UniProt Synonym Gene Names
C11orf11; KIAA0659; NSDDR; DGL-alpha  [Similar Products]
UniProt Entry Name
DGLA_HUMAN
NCBI Summary for DAGLA
This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]
UniProt Comments for DAGLA
NSDDR: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. Defects in DAGLA may be a cause of spinocerebellar ataxia type 20 (SCA20). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA20 is an autosomal dominant, adult- onset form characterized by dysarthria due to spasmodic dysphonia followed by slowly progressive ataxia. A copy number variation consisting of a 260-kb duplication at chromosome 11q12.2-12.3 is responsible for SCA20. The critical gene within the duplicated segment may be DAGLA. Belongs to the AB hydrolase superfamily. Lipase family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Hydrolase; EC 3.1.1.-

Chromosomal Location of Human Ortholog: 11q12.2

Cellular Component: integral to membrane; plasma membrane

Molecular Function: acylglycerol lipase activity; metal ion binding

Biological Process: arachidonic acid metabolic process; diacylglycerol catabolic process; neuroblast proliferation; neurotransmitter biosynthetic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-DAGLA antibody
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