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anti-DDR1 antibody :: Rabbit DDR1 Polyclonal Antibody

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Catalog # MBS9503324
Unit / Price
  0.05 mg  /  $225 +1 FREE 8GB USB
  0.1 mg  /  $310 +1 FREE 8GB USB
Product Name

DDR1, Polyclonal Antibody

Popular Item
Full Product Name

DDR1 (Phospho-Tyr513) Antibody

Product Synonym Names
CAK; CD167a antigen; Cell adhesion kinase; Discoidin receptor tyrosine kinase; EDDR1; Epithelial discoidin domain receptor 1 precursor; HGK2; Protein-tyrosine kinase RTK 6; RTK6; TRK E; TRKE; Tyrosine kinase DDR; Tyrosine- protein kinase CAK
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
X74979 mRNA
3D Structure
ModBase 3D Structure for Q08345
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
DDR1 (Phospho-Tyr513) Antibody detects endogenous levels of DDR1 only when phosphorylated at Tyr513.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Phospho
Modification Sites
H:Y513; M:Y511; R:Y510
Immunogen
The antiserum was produced against synthesized peptide derived from human DDR1 around the phosphorylation site of Tyr513.
Immunogen Range
479-528
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-DDR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DDR1 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-DDR1 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000

Immunohistochemistry (IHC) of anti-DDR1 antibody
Immunohistochemistry analysis of paraffin-embedded human brain, using DDR1 (Phospho-Tyr513) Antibody. The picture on the right is blocked with the phospho peptide.
anti-DDR1 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-DDR1 antibody
Western blot analysis of lysates from HepG2 cells treated with Na3VO4 0.3mM 40', using DDR1 (Phospho-Tyr513) Antibody. The lane on the right is blocked with the phospho peptide.
anti-DDR1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for DDR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
101 kDa
NCBI Official Full Name
epithelial discoidin domain-containing receptor 1 isoform 4
NCBI Official Synonym Full Names
discoidin domain receptor tyrosine kinase 1
NCBI Official Symbol
NCBI Official Synonym Symbols
CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A
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NCBI Protein Information
epithelial discoidin domain-containing receptor 1
UniProt Protein Name
Epithelial discoidin domain-containing receptor 1
UniProt Synonym Protein Names
CD167 antigen-like family member A; Cell adhesion kinase; Discoidin receptor tyrosine kinase; HGK2; Mammary carcinoma kinase 10; MCK-10; Protein-tyrosine kinase 3A; Protein-tyrosine kinase RTK-6; TRK E; Tyrosine kinase DDR; Tyrosine-protein kinase CAK; CD_antigen: CD167a
UniProt Gene Name
UniProt Synonym Gene Names
CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; Epithelial discoidin domain receptor 1; MCK-10  [Similar Products]
NCBI Summary for DDR1
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
UniProt Comments for DDR1
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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