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anti-DOCK8 antibody :: Rabbit dedicator of cytokinesis 8 Polyclonal Antibody

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Catalog # MBS716668
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-DOCK8 antibody
Product Name

dedicator of cytokinesis 8 (DOCK8), Polyclonal Antibody

Also Known As

Rabbit anti-human dedicator of cytokinesis 8 polyclonal Antibody

Product Synonym Names
dedicator of cytokinesis 8; DOCK8; FLJ00026; FLJ00152; FLJ00346; MRD2; ZIR8
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
gene 614113
Species Reactivity
Human, Mouse, Rat
Antigen Affinity Purified
Human DOCK8
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-104911 / sc-292124
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-DOCK8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DOCK8 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for DOCK8. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
227,477 Da[Similar Products]
NCBI Official Full Name
dedicator of cytokinesis protein 8 isoform 3
NCBI Official Synonym Full Names
dedicator of cytokinesis 8
NCBI Official Symbol
DOCK8  [Similar Products]
NCBI Official Synonym Symbols
MRD2; ZIR8; HEL-205
  [Similar Products]
NCBI Protein Information
dedicator of cytokinesis protein 8; 1200017A24Rik; epididymis luminal protein 205
UniProt Protein Name
Dedicator of cytokinesis protein 8
UniProt Gene Name
DOCK8  [Similar Products]
UniProt Entry Name
NCBI Summary for DOCK8
This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
UniProt Comments for DOCK8
DOCK8: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Defects in DOCK8 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal recessive (AR-HIES). It is a rare disorder of immunity characterized by immunodeficiency, recurrent infections, eczema, increased serum IgE, eosinophilia and lack of connective tissue and skeletal involvement. Defects in DOCK8 are the cause of mental retardation autosomal dominant type 2 (MRD2). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. A chromosomal aberration disrupting DOCK8 has been found in a patient with mental retardation and ectodermal dysplasia. DOCK8 is disrupted in patients with mental retardation. A balanced translocation, t(X;9) (q13.1;p24). Belongs to the DOCK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; GEFs; GEFs, misc.

Chromosomal Location of Human Ortholog: 9p24.3

Cellular Component: membrane; leading edge; cytosol

Molecular Function: protein binding; guanyl-nucleotide exchange factor activity

Biological Process: formation of immunological synapse; small GTPase mediated signal transduction; blood coagulation; positive regulation of GTPase activity

Disease: Mental Retardation, Autosomal Dominant 2; Hyper-ige Recurrent Infection Syndrome, Autosomal Recessive
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