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anti-DNASE2 antibody :: Rabbit deoxyribonuclease II, lysosomal Polyclonal Antibody

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Catalog # MBS714026
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-DNASE2 antibody
Product Name

deoxyribonuclease II, lysosomal (DNASE2), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human deoxyribonuclease II, lysosomal polyclonal Antibody

Product Synonym Names
deoxyribonuclease II; lysosomal; DNASE2; DNASE2A; DNL; DNL2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
126350
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human DNASE2
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-19271 / sc-19272
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-DNASE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DNASE2 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for DNASE2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,615 Da[Similar Products]
NCBI Official Full Name
Deoxyribonuclease II, lysosomal
NCBI Official Synonym Full Names
deoxyribonuclease II, lysosomal
NCBI Official Symbol
DNASE2  [Similar Products]
NCBI Official Synonym Symbols
DNL; DNL2; DNASE2A
  [Similar Products]
NCBI Protein Information
deoxyribonuclease-2-alpha; R31240_2; acid DNase; DNase II alpha; lysosomal DNase II; DNase II, lysosomal; deoxyribonuclease II alpha
UniProt Protein Name
Deoxyribonuclease-2-alpha
UniProt Synonym Protein Names
Acid DNase; Deoxyribonuclease II alpha; DNase II alpha; Lysosomal DNase II; R31240_2
Protein Family
UniProt Gene Name
DNASE2  [Similar Products]
UniProt Synonym Gene Names
DNASE2A; DNL2; DNase II alpha  [Similar Products]
UniProt Entry Name
DNS2A_HUMAN
NCBI Summary for DNASE2
This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record. [provided by RefSeq, Jul 2008]
UniProt Comments for DNASE2
DNASE2: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells. Belongs to the DNase II family.

Protein type: Deoxyribonuclease; EC 3.1.22.1

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: lysosome; intracellular

Molecular Function: deoxyribonuclease II activity; DNA binding

Biological Process: erythrocyte differentiation; DNA fragmentation during apoptosis; DNA metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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