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anti-DICER1 antibody :: Rabbit dicer 1, ribonuclease type III Polyclonal Antibody

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Catalog # MBS712147
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-DICER1 antibody
Product Name

dicer 1, ribonuclease type III (DICER1), Polyclonal Antibody

Also Known As

Rabbit anti-human dicer 1, ribonuclease type III polyclonal Antibody

Product Synonym Names
dicer 1; ribonuclease type III; DICER1; DCR1; Dicer; HERNA; KIAA0928
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1922
OMIM
606241
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human DICER1
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-25117 / sc-34602 / sc-34601 / sc-34600 / sc-30226
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-DICER1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DICER1 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for DICER1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
92,726 Da[Similar Products]
NCBI Official Full Name
Dicer 1, ribonuclease type III
NCBI Official Synonym Full Names
dicer 1, ribonuclease type III
NCBI Official Symbol
DICER1  [Similar Products]
NCBI Official Synonym Symbols
DCR1; MNG1; Dicer; HERNA; RMSE2; Dicer1e
  [Similar Products]
NCBI Protein Information
endoribonuclease Dicer; K12H4.8-LIKE; helicase MOI; helicase-moi; Dicer1, Dcr-1 homolog; multinodular goitre 1; helicase with RNAse motif; dicer 1, double-stranded RNA-specific endoribonuclease
UniProt Protein Name
Endoribonuclease Dicer
UniProt Synonym Protein Names
Helicase with RNase motif; Helicase MOI
Protein Family
UniProt Gene Name
DICER1  [Similar Products]
UniProt Synonym Gene Names
DICER; HERNA; KIAA0928; Helicase MOI  [Similar Products]
UniProt Entry Name
DICER_HUMAN
NCBI Summary for DICER1
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
UniProt Comments for DICER1
DICER1: a cytoplasmic type-III RNase that plays a central role in RNA interference (RNAi) pathways to produce the active small RNAs that represses gene expression. Possesses a DEAD box RNA helicase motif in its amino terminus and a dsRNA-binding motif in the carboxy terminus. Dicer, along with Ago2 andTRBP, are the main components of the RNA-induced silencing complex (RISC). Fragile X syndrome repeats form RNA hairpins that are cut by Dicer but do not activate the interferon-inducible protein kinase, PKR. Four alternatively spliced isoforms have been described.

Protein type: Ribonuclease; EC 3.1.26.3; RNA-binding; RNA processing; Helicase; Cell development/differentiation

Chromosomal Location of Human Ortholog: 14q32.13

Cellular Component: growth cone; axon; cytoplasm; dendrite; ER-Golgi intermediate compartment; nucleus; cytosol

Molecular Function: endoribonuclease activity; protein binding; ribonuclease III activity; miRNA binding; metal ion binding; double-stranded RNA binding; deoxyribonuclease I activity; helicase activity; ATP binding

Biological Process: zygote asymmetric cell division; regulation of cell cycle; regulation of neuron differentiation; regulation of oligodendrocyte differentiation; miRNA-mediated gene silencing, miRNA loading onto RISC; negative regulation of transcription from RNA polymerase II promoter; olfactory bulb interneuron differentiation; embryonic hindlimb morphogenesis; post-embryonic development; cardiac muscle cell development; pre-microRNA processing; angiogenesis; DNA fragmentation during apoptosis; regulation of viral genome replication; defense response to virus; spleen development; positive regulation of myelination; positive regulation of Schwann cell differentiation; hair follicle morphogenesis; inner ear receptor cell development; multicellular organism growth; RNA interference, targeting of mRNA for destruction; mRNA stabilization; stem cell maintenance; RNA interference, conversion of ds siRNA to ss siRNA; spindle assembly; spinal cord motor neuron differentiation; miRNA-mediated gene silencing, production of miRNAs; myelin formation in the peripheral nervous system; branching morphogenesis of a tube; cartilage development; nerve development; gene expression; cerebral cortex development; reproductive structure development; RNA interference, production of siRNA; neurite morphogenesis; myoblast cell differentiation involved in skeletal muscle regeneration; lung development

Disease: Pleuropulmonary Blastoma; Goiter, Multinodular 1, With Or Without Sertoli-leydig Cell Tumors; Rhabdomyosarcoma, Embryonal, 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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