NP_004414.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
76,256 Da
NCBI Official Full Name
segment polarity protein dishevelled homolog DVL-3
NCBI Official Synonym Full Names
dishevelled segment polarity protein 3
NCBI Protein Information
segment polarity protein dishevelled homolog DVL-3; DSH homolog 3; dishevelled-3; dishevelled, dsh homolog 3; dishevelled 3 (homologous to Drosophila dsh)
UniProt Protein Name
Segment polarity protein dishevelled homolog DVL-3
UniProt Synonym Protein Names
DSH homolog 3
UniProt Synonym Gene Names
UniProt Entry Name
DVL3_HUMAN
NCBI Summary for DVL3
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008]
UniProt Comments for DVL3
DVL3: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q27
Cellular Component: cytosol
Molecular Function: protein binding; protease binding; frizzled binding; protein heterodimerization activity; beta-catenin binding; receptor binding
Biological Process: response to drug; positive regulation of JNK activity; Wnt receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of transcription, DNA-dependent; positive regulation of protein amino acid phosphorylation; Wnt receptor signaling pathway through beta-catenin
Research Articles on DVL3
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Products associated with anti-DVL3 antibody
Pathways associated with anti-DVL3 antibody
Diseases associated with anti-DVL3 antibody
Organs/Tissues associated with anti-DVL3 antibody
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