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anti-DLL1 antibody :: Goat DLL1 Polyclonal Antibody

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Catalog # MBS422082
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

DLL1, Polyclonal Antibody

Full Product Name

Goat anti-DLL1 Antibody

Product Synonym Names
DLL1; delta-like 1 (Drosophila); DELTA1; DL1; Delta; OTTHUMP00000017690; delta (Drosophila)-like 1; delta-like 1; delta-like 1 protein; DLL1 antibody; delta-like 1 (Drosophila) antibody; DELTA1 antibody; DL1 antibody; Delta antibody; OTTHUMP00000017690 antibody; delta (Drosophila)-like 1 antibody; delta-like 1 antibody; delta-like 1 protein antibody
Product Gene Name

anti-DLL1 antibody

[Similar Products]
Antibody/Peptide Pairs
DLL1 peptide (MBS425938) is used for blocking the activity of DLL1 antibody (MBS422082)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Immunogen Sequence
ATQRHLTVGE EWSQD
OMIM
606582
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-ATQRHLTVGEEWSQD, from the internal region of the protein sequence according to NP_005609.3.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-DLL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Applications Tested/Suitable for anti-DLL1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-DLL1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx.75kDa band observed in Mouse Heart and Rat Heart lysates (calculated MW of 78.1kDa according to Human NP_005609.3, 78.5kDa according to Mouse NP_031891.2 and 77.4kDa according to Rat NP_114452.1). Recommended concentration: 0.3-1ug/ml.
Western Blot (WB) of anti-DLL1 antibody
(0.3ug/ml) staining of Rat Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-DLL1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for DLL1. It may not necessarily be applicable to this product.
NCBI GI #
110735443
NCBI GeneID
28514
NCBI Accession #
NP_005609.3 [Other Products]
NCBI GenBank Nucleotide #
NM_005618.3 [Other Products]
UniProt Secondary Accession #
Q9NU41; Q9UJV2; B2RAK7; B5M0B3[Other Products]
UniProt Related Accession #
O00548[Other Products]
Molecular Weight
27,355 Da
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NCBI Official Full Name
delta-like protein 1
NCBI Official Synonym Full Names
delta like canonical Notch ligand 1
NCBI Official Symbol
DLL1  [Similar Products]
NCBI Official Synonym Symbols
DL1; Delta; DELTA1
  [Similar Products]
NCBI Protein Information
delta-like protein 1
UniProt Protein Name
Delta-like protein 1
UniProt Synonym Protein Names
Drosophila Delta homolog 1; Delta1; H-Delta-1
Protein Family
Delta-like protein
UniProt Gene Name
DLL1  [Similar Products]
UniProt Synonym Gene Names
Delta1; H-Delta-1  [Similar Products]
UniProt Entry Name
DLL1_HUMAN
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NCBI Summary for DLL1
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]
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UniProt Comments for DLL1
DLL1: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: adherens junction; apical plasma membrane; cytoplasmic vesicle; extracellular region; integral to plasma membrane; lipid raft; plasma membrane

Molecular Function: calcium ion binding; Notch binding; protein binding; Tat protein binding

Biological Process: astrocyte development; cell differentiation; cell fate determination; cerebellar molecular layer formation; cerebellar Purkinje cell layer structural organization; compartment specification; determination of left/right symmetry; heart looping; hemopoiesis; inner ear development; lateral inhibition; marginal zone B cell differentiation; negative regulation of auditory receptor cell differentiation; negative regulation of cell differentiation; negative regulation of cell proliferation; negative regulation of epidermal cell differentiation; negative regulation of epithelial cell differentiation; negative regulation of interleukin-10 production; negative regulation of myeloid cell differentiation; negative regulation of myoblast differentiation; negative regulation of neuron differentiation; neuron fate specification; Notch receptor processing; Notch signaling pathway; organ growth; positive regulation of cell proliferation; positive regulation of endocytosis; positive regulation of Notch signaling pathway; positive regulation of skeletal muscle growth; positive regulation of transcription from RNA polymerase II promoter; proximal/distal pattern formation; regulation of blood pressure; regulation of cell adhesion; regulation of cell division; regulation of growth; regulation of neurogenesis; regulation of skeletal muscle growth; regulation of somitogenesis; retina development in camera-type eye; retina morphogenesis in camera-type eye; skeletal muscle growth; somite specification; somitogenesis; spinal cord development
Research Articles on DLL1
1. Although Delta1 activates signal transducer and activator of transcription 3 signaling similarly to the gp130-activating cytokine interleukin-6 (IL-6), it has opposite effects on myeloid cell production.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated withanti-DLL1 antibody
 Reference Product  PubMed Publications
 NOTCH1 antibody  >134 publications with DLL1 and NOTCH1
 NOTCH3 antibody  >23 publications with DLL1 and NOTCH3
 NOTCH4 antibody  >19 publications with DLL1 and NOTCH4
 MIB1 antibody  >6 publications with DLL1 and MIB1
 PSEN1 antibody  >3 publications with DLL1 and PSEN1
 ADAM12 antibody  >3 publications with DLL1 and ADAM12
 ADAM10 antibody  >3 publications with DLL1 and ADAM10
Pathways associated with anti-DLL1 antibody
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies  NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
Diseases associated with anti-DLL1 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >15 publications with DLL1 and Carcinoma
 Disease Models, Animal Antibodies  >13 publications with DLL1 and Disease Models, Animal
 Congenital Abnormalities Antibodies  >12 publications with DLL1 and Congenital Abnormalities
 Inflammation Antibodies  >11 publications with DLL1 and Inflammation
 Immune System Diseases Antibodies  >11 publications with DLL1 and Immune System Diseases
 Lung Diseases Antibodies  >8 publications with DLL1 and Lung Diseases
 Neovascularization, Pathologic Antibodies  >7 publications with DLL1 and Neovascularization, Pathologic
 Neoplasms, Experimental Antibodies  >6 publications with DLL1 and Neoplasms, Experimental
 Abnormalities, Multiple Antibodies  >6 publications with DLL1 and Abnormalities, Multiple
 Lung Neoplasms Antibodies  >5 publications with DLL1 and Lung Neoplasms
Organs/Tissues associated with anti-DLL1 antibody
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >46 publications with DLL1 and Embryonic Tissue
 Brain Antibodies  >41 publications with DLL1 and Brain
 Lung Antibodies  >18 publications with DLL1 and Lung
 Intestine Antibodies  >15 publications with DLL1 and Intestine
 Kidney Antibodies  >9 publications with DLL1 and Kidney
 Eye Antibodies  >9 publications with DLL1 and Eye
 Ear Antibodies  >6 publications with DLL1 and Ear
 Skin Antibodies  >6 publications with DLL1 and Skin
 Lymph Node Antibodies  >5 publications with DLL1 and Lymph Node
 Placenta Antibodies  >4 publications with DLL1 and Placenta
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