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anti-DUET antibody :: Rabbit DUET Polyclonal Antibody

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Catalog # MBS9602948
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Western Blot (WB)
Product Name

DUET, Polyclonal Antibody

Popular Item
Full Product Name

DUET Antibody

Product Synonym Names
Duo; FLJ16443; HAPIP; Huntingtin associated protein interacting protein (duo); Huntingtin-associated protein-interacting protein; Kalirin (isoform 2); Kalirin; KALRN; KALRN_HUMAN; Protein Duo; RhoGEF kinase; Serine/threonine kinase with Dbl and pleckstrin homology domains; Serine/threonine-protein kinase with Dbl-and pleckstrin homology domain; TRAD
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O60229
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
DUET antibody detects endogenous levels of total DUET
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human DUET
Subcellular Location
Cytoskeleton
Tissue Specificity
Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-DUET antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DUET antibody
Function: Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Subunit Structure: Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity). Interacts with FASLG.
Post-translational Modifications: Autophosphorylated.
Similarity: The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Applications Tested/Suitable for anti-DUET antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-DUET antibody
WB: 1:1000-3000

Western Blot (WB) of anti-DUET antibody
Western blot analysis of DUET using HUVEC whole cell lysates
anti-DUET antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for DUET. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 340 kDa
Predicted: 341 kDa
NCBI Official Full Name
kalirin isoform 1
NCBI Official Synonym Full Names
kalirin RhoGEF kinase
NCBI Official Symbol
KALRN  [Similar Products]
NCBI Official Synonym Symbols
DUO; CHD5; DUET; TRAD; CHDS5; HAPIP; ARHGEF24
  [Similar Products]
NCBI Protein Information
kalirin
UniProt Protein Name
Kalirin
UniProt Synonym Protein Names
Huntingtin-associated protein-interacting protein; Protein Duo; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
UniProt Gene Name
KALRN  [Similar Products]
NCBI Summary for DUET
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]
UniProt Comments for DUET
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-DUET antibody
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