BC009778
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,283 Da
NCBI Official Full Name
Homo sapiens dual specificity phosphatase 13, mRNA
NCBI Official Synonym Full Names
dual specificity phosphatase 13
NCBI Official Synonym Symbols
BEDP; MDSP; TMDP; SKRP4; DUSP13A; DUSP13B [Similar Products]
NCBI Protein Information
dual specificity protein phosphatase 13; branching-enzyme interacting DSP; branching-enzyme interacting dual-specificity protein phosphatase; muscle-restricted DSP; testis- and skeletal-muscle-specific DSP
UniProt Protein Name
Dual specificity protein phosphatase 13 isoform A
UniProt Synonym Protein Names
Branching-enzyme interacting DSP; Muscle-restricted DSP; MDSP
UniProt Entry Name
DS13A_HUMAN
NCBI Summary for DUSP13
Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]
UniProt Comments for DUSP13
DUSP13 iso5: May be involved in the regulation of meiosis and/or differentiation of testicular germ cells during spermatogenesis. Exhibits intrinsic phosphatase activity towards both phospho- seryl/threonyl and -tyrosyl residues of myelin basic protein, with similar specific activities in vitro. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 5 isoforms of the human protein are produced by alternative promoter.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; EC 3.1.3.16; Cell cycle regulation; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 10q22.2
Cellular Component: cytoplasm
Molecular Function: protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: meiosis; spermatogenesis; protein amino acid dephosphorylation
Product References and Citations for anti-DUSP13 antibody
(1) Katagiri,C., Masuda,K., Nomura,M. et al. DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression. Mol. Cell. Biochem. 352 (1-2), 155-162 (2011)
Research Articles on DUSP13
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Diseases associated with anti-DUSP13 antibody
Organs/Tissues associated with anti-DUSP13 antibody
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