NP_001129611.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,510 Da
NCBI Official Full Name
transcription factor E2-alpha isoform E47
NCBI Official Synonym Full Names
transcription factor 3
NCBI Official Synonym Symbols
E2A; E47; ITF1; VDIR; TCF-3; bHLHb21 [Similar Products]
NCBI Protein Information
transcription factor E2-alpha
UniProt Protein Name
Transcription factor E2-alpha
UniProt Synonym Protein Names
Class B basic helix-loop-helix protein 21; bHLHb21; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription factor 3; TCF-3; Transcription factor ITF-1
UniProt Synonym Gene Names
UniProt Entry Name
TFE2_HUMAN
NCBI Summary for E2A
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
UniProt Comments for E2A
E2A: a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.
Protein type: Transcription factor; DNA-binding; Oncoprotein
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: nucleoplasm; transcription factor complex; protein complex; nuclear chromatin; cytoplasm; nucleus
Molecular Function: protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; transcription coactivator activity; bHLH transcription factor binding; chromatin binding; mitogen-activated protein kinase kinase kinase binding; transcription factor binding; transcription factor activity
Biological Process: response to drug; Peyer's patch development; immunoglobulin V(D)J recombination; transcription, DNA-dependent; protein stabilization; B cell lineage commitment; positive regulation of transcription, DNA-dependent; T cell differentiation in the thymus; positive regulation of cell cycle; response to lipopolysaccharide; negative regulation of transcription from RNA polymerase II promoter; muscle cell differentiation; regulation of transcription, DNA-dependent; natural killer cell differentiation; B cell differentiation; positive regulation of B cell proliferation; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of neuron differentiation; cell development
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Products associated with anti-E2A antibody
Pathways associated with anti-E2A antibody
Diseases associated with anti-E2A antibody
Organs/Tissues associated with anti-E2A antibody
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