P60842.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 39kDa/46kDa 46kDa
NCBI Official Full Name
Eukaryotic initiation factor 4A-I
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 4A1
NCBI Official Synonym Symbols
DDX2A; EIF4A; EIF-4A; eIF4A-I; eIF-4A-I [Similar Products]
NCBI Protein Information
eukaryotic initiation factor 4A-I; eukaryotic initiation factor 4AI; ATP-dependent RNA helicase eIF4A-1; eukaryotic translation initiation factor 4A, isoform 1
UniProt Protein Name
Eukaryotic initiation factor 4A-I
UniProt Synonym Protein Names
ATP-dependent RNA helicase eIF4A-1
UniProt Synonym Gene Names
UniProt Entry Name
IF4A1_HUMAN
UniProt Comments for EIF4A1
EIF4A1: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and UPF2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1. Interacts with PDCD4; this interferes with the interaction between EIF4A and EIF4G. Interacts with RBM4. Interacts with human cytomegalovirus/HHV-5 protein UL69. Helicase activity and function in translation are inhibited by interaction with PDCD4. Belongs to the DEAD box helicase family. eIF4A subfamily.
Protein type: RNA-binding; Translation; EC 3.6.4.13; Helicase; Translation initiation
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: membrane; eukaryotic translation initiation factor 4F complex; cytoplasm; nucleus; cytosol
Molecular Function: mRNA binding; protein binding; translation factor activity, nucleic acid binding; translation initiation factor activity; double-stranded RNA binding; helicase activity; ATP binding; RNA cap binding
Biological Process: poly(A) tail shortening; organ regeneration; cellular protein metabolic process; translation; viral reproduction; cytokine and chemokine mediated signaling pathway; translational initiation; gene expression; mRNA catabolic process, deadenylation-dependent decay
Research Articles on EIF4A1
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Products associated with anti-EIF4A1 antibody
Pathways associated with anti-EIF4A1 antibody
Diseases associated with anti-EIF4A1 antibody
Organs/Tissues associated with anti-EIF4A1 antibody
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