NP_001005915.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
77,426 Da
NCBI Official Full Name
receptor tyrosine-protein kinase erbB-3 isoform s
NCBI Official Synonym Full Names
erb-b2 receptor tyrosine kinase 3
NCBI Official Synonym Symbols
HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3 [Similar Products]
NCBI Protein Information
receptor tyrosine-protein kinase erbB-3
UniProt Protein Name
Receptor tyrosine-protein kinase erbB-3
UniProt Synonym Protein Names
Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3
UniProt Synonym Gene Names
UniProt Entry Name
ERBB3_HUMAN
NCBI Summary for ErbB-3
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for ErbB-3
HER3: a receptor tyrosine kinase of the EGFR family. Binds and is activated by neuregulins and NTAK. Can form homodimers or ErbB-2/ErbB-3 heterodimers. Kinase domain lacks activity but heterodimerizes with other EGFRs to transduce growth signals. May be required for HER2 activity. Elevated expression in breast and other tumors is indicative of poor outcome. A secreted form is expressed in metastatic prostate cancer Two alternatively spliced isoforms have been described.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Oncoprotein; Membrane protein, integral; Kinase, protein; TK group; EGFR family
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: extracellular space; basolateral plasma membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; receptor complex; lateral plasma membrane
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; transmembrane receptor activity; protein heterodimerization activity; growth factor binding; protein-tyrosine kinase activity; protein tyrosine kinase activator activity; ATP binding
Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide 3-kinase cascade; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; wound healing; heart development; cranial nerve development; negative regulation of cell adhesion; signal transduction; protein amino acid phosphorylation; negative regulation of signal transduction; regulation of cell proliferation; peripheral nervous system development; positive regulation of phosphoinositide 3-kinase cascade; Schwann cell differentiation; neuron apoptosis; innate immune response; negative regulation of secretion; negative regulation of neuron apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Lethal Congenital Contracture Syndrome 2
Research Articles on ErbB-3
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Products associated with anti-ErbB-3 antibody
Pathways associated with anti-ErbB-3 antibody
Diseases associated with anti-ErbB-3 antibody
Organs/Tissues associated with anti-ErbB-3 antibody
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