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anti-FEZ2 antibody :: Rabbit FEZ2 Polyclonal Antibody

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Catalog # MBS151297
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

FEZ2, Polyclonal Antibody

Also Known As

FEZ2 Antibody

Product Synonym Names
FEZ2; HUM3CL; Fasciculation and elongation protein zeta-2; Zygin II; fasciculation and elongation protein zeta 2 (zygin II)
Antibody/Peptide Pairs
FEZ2 peptide (MBS153200) is used for blocking the activity of FEZ2 antibody (MBS151297)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
380
OMIM
604826
3D Structure
ModBase 3D Structure for Q9UHY8
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
FEZ2 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Conjugate
Unconjugated
Immunogen
FEZ2 antibody was raised against a 15 amino acid synthetic peptide from near the center of human FEZ2.
Buffer
FEZ2 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
FEZ2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-FEZ2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FEZ2 antibody
FEZ2 Antibody: Fasciculation and elongation protein zeta-2 (FEZ2) is a homolog to the mammalian FEZ1, itself an ortholog of the C. elegans UNC-76. In contrast to FEZ1, FEZ2 mRNA is widely expressed in mouse tissues. FEZ2 interacts with protein kinase C (PKC)-zeta substrate and induces neurite extension of PC12 cells when co-expressed with a constitutively active form of PKC-zeta, suggesting FEZ2 may play an important role in the morphological changes of various cells by associating with PKC-zeta in a tissue non-specific manner. FEZ2 can interact with FEZ1 through its c-terminal regions and especially its coiled-coil region. At least two isoforms of FEZ2 are known to exist.
Applications Tested/Suitable for anti-FEZ2 antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-FEZ2 antibody
FEZ2 antibody can be used for the detection of FEZ2 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunoflourescence starting at 5 mug/mL. For immunofluorescence start at 5 mug/mL.

Western Blot (WB) of anti-FEZ2 antibody
Western blot analysis of FEZ2 in 3T3 cell lysate with FEZ2 antibody at (A) 0.5, and (B) 1 μg/mL.
anti-FEZ2 antibody Western Blot (WB) (WB) image
Immunofluorescence (IF) of anti-FEZ2 antibody
Immunofluorescence of human brain tissue using FEZ2 antibody at 5 μg/mL.
anti-FEZ2 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for FEZ2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,613 Da
NCBI Official Full Name
fasciculation and elongation protein zeta-2 isoform 2
NCBI Official Synonym Full Names
fasciculation and elongation protein zeta 2 (zygin II)
NCBI Official Symbol
NCBI Official Synonym Symbols
HUM3CL
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NCBI Protein Information
fasciculation and elongation protein zeta-2; zygin 2; zygin-2; zygin II; pre-T/NK cell associated protein (3Cl)
UniProt Protein Name
Fasciculation and elongation protein zeta-2
UniProt Synonym Protein Names
Zygin II; Zygin-2
UniProt Gene Name
UniProt Entry Name
FEZ2_HUMAN
NCBI Summary for FEZ2
This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]
UniProt Comments for FEZ2
FEZ2: Involved in axonal outgrowth and fasciculation. Belongs to the zygin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 2p21

Molecular Function: protein binding

Biological Process: axon guidance; nervous system development; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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