AAI43755.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 263 Observed MW: 260
NCBI Official Full Name
FN1 protein
NCBI Official Synonym Full Names
fibronectin 1
NCBI Official Synonym Symbols
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2 [Similar Products]
NCBI Protein Information
fibronectin
UniProt Protein Name
Fibronectin
UniProt Synonym Protein Names
Cold-insoluble globulin; CIG
UniProt Synonym Gene Names
UniProt Entry Name
FINC_HUMAN
NCBI Summary for FN1
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
UniProt Comments for FN1
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.
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Pathways associated with anti-FN1 antibody
Diseases associated with anti-FN1 antibody
Organs/Tissues associated with anti-FN1 antibody
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