NP_003584.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,925 Da
NCBI Official Full Name
forkhead box protein N1
NCBI Official Synonym Full Names
forkhead box N1
NCBI Protein Information
forkhead box protein N1; Rowett nude; winged helix nude; winged-helix nude; winged-helix transcription factor nude
UniProt Protein Name
Forkhead box protein N1
UniProt Synonym Protein Names
Winged-helix transcription factor nude
UniProt Synonym Gene Names
UniProt Entry Name
FOXN1_HUMAN
NCBI Summary for FOXN1
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008]
UniProt Comments for FOXN1
FOXN1: Transcriptional regulator involved in development. Defects in FOXN1 are the cause of T-cell immunodeficiency congenital alopecia and nail dystrophy (TIDAND). A disorder characterized by the association of congenital alopecia, severe T-cell immunodeficiency, and ridging and pitting of all nails.
Protein type: DNA-binding; Transcription factor; Cell development/differentiation
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding
Biological Process: keratinocyte differentiation; transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; epithelial cell proliferation; epidermis development; organ morphogenesis; hair follicle development; thymus development; regulation of T cell differentiation in the thymus; defense response; lymphocyte homeostasis
Disease: T-cell Immunodeficiency, Congenital Alopecia, And Nail Dystrophy
Research Articles on FOXN1
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Products associated with anti-FOXN1 antibody
Diseases associated with anti-FOXN1 antibody
Organs/Tissues associated with anti-FOXN1 antibody
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