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anti-GABBR2 antibody :: Rabbit GABBR2 Polyclonal Antibody

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Catalog # MBS9212541
Unit / Price
  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Product Name

GABBR2, Polyclonal Antibody

Popular Item
Full Product Name

GABBR2 Antibody (C-term)

Product Synonym Names
Gamma-aminobutyric acid type B receptor subunit 2; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2; G-protein coupled receptor 51; HG20; GABBR2; GPR51; GPRC3B
Antibody/Peptide Pairs
GABBR2 peptide (MBS9217485) is used for blocking the activity of GABBR2 antibody (MBS9212541)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
861-890
OMIM
607340
3D Structure
ModBase 3D Structure for O75899
Clonality
Polyclonal
Isotype
Rabbit Ig
Clone Number
RB24610
Host
Rabbit
Species Reactivity
Human, Mouse, (Predicted Reactivity: Rat)
Specificity
This GABBR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 861-890 amino acids from the C-terminal region of human GABBR2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterod- imeric GABA receptor , only GABBR1 seem s to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase . Signaling inhibits adenylate cyclase, stimulates phospholipase A2 , activates potassium channels , inactivates voltage-dependent calcium -channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transm ission. Pre-synaptic GABA receptor inhibits neurotransm itter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
Cellualr Location
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; MuIti-pass membrane protein . Note= Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane . In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane.
Tissue Location
Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla Weakly expressed in heart, testis and skeletal muscle.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-GABBR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GABBR2 antibody
The multi-pass membrane protein encoded by this gene
belongs to the G-protein coupled receptor 3 family and GABA-B
receptor subfamily. The GABA-B receptors inhibit neuronal activity
through G protein-coupled second-messenger systems, which regulate
the release of neurotransmitters, and the activity of ion channels
and adenylyl cyclase. This receptor subunit forms an active
heterodimeric complex with GABA-B receptor subunit 1, neither of
which is effective on its own. Allelic variants of this gene have
been associated with nicotine dependence.
Product Categories/Family for anti-GABBR2 antibody
Applications Tested/Suitable for anti-GABBR2 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC-P)
Application Notes for anti-GABBR2 antibody
WB~~1:1000
IHC-P~~1:50~100

Western Blot (WB) of anti-GABBR2 antibody
GABBR2 Antibody (C-term) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the GABBR2 antibody detected the GABBR2 protein (arrow).
anti-GABBR2 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-GABBR2 antibody
GABBR2 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GABBR2 antibody detected the GABBR2 protein (arrow).
anti-GABBR2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-GABBR2 antibody
GABBR2 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GABBR2 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-GABBR2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for GABBR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
105821
NCBI Official Full Name
gamma-aminobutyric acid type B receptor subunit 2
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) B receptor, 2
NCBI Official Symbol
GABBR2  [Similar Products]
NCBI Official Synonym Symbols
HG20; GPR51; GPRC3B; GABABR2; HRIHFB2099
  [Similar Products]
NCBI Protein Information
gamma-aminobutyric acid type B receptor subunit 2
UniProt Protein Name
Gamma-aminobutyric acid type B receptor subunit 2
UniProt Synonym Protein Names
G-protein coupled receptor 51; HG20
UniProt Gene Name
GABBR2  [Similar Products]
UniProt Synonym Gene Names
GPR51; GPRC3B; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2  [Similar Products]
UniProt Entry Name
GABR2_HUMAN
NCBI Summary for GABBR2
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
UniProt Comments for GABBR2
GABBR2: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region. Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 3

Chromosomal Location of Human Ortholog: 9q22.1-q22.3

Cellular Component: postsynaptic membrane; neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; cell junction

Molecular Function: protein binding; GABA-B receptor activity

Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; negative regulation of adenylate cyclase activity; gamma-aminobutyric acid signaling pathway

Disease: Tobacco Addiction, Susceptibility To
Product References and Citations for anti-GABBR2 antibody
Oblak, A.L., et al. J. Neurochem. 114(5):1414-1423(2010)
Letra, A., et al. Am. J. Med. Genet. A 152A (7), 1701-1710 (2010) :
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :

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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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