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anti-Gfra1 antibody :: Rabbit GFR alpha1, IN Polyclonal Antibody

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Catalog # MBS611148
Unit / Price
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  0.1 mg  /  $595 +1 FREE 8GB USB
anti-Gfra1 antibody
Product Name

GFR alpha1, IN (Gfra1), Polyclonal Antibody

Full Product Name

GFR alpha1, IN (GDNFRa, Glial Cell-derived Neurotrophic Factor Receptor a1, RETL1, Ret ligand 1, TGFb-related Neurotrophic Factor Receptor 1, TrnR1, Glycosylphosphadidylinositol linked Protein)

Product Synonym Names
Anti -GFR alpha1, IN (GDNFRa, Glial Cell-derived Neurotrophic Factor Receptor a1, RETL1, Ret ligand 1, TGFb-related Neurotrophic Factor Receptor 1, TrnR1, Glycosylphosphadidylinositol linked Protein)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_005100.2 (264614329..264875486, complement). Location: 1q55
3D Structure
ModBase 3D Structure for Q62997
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes GDNFR alpha, a cell surface receptor for glial cell derived neutrophic factor (GDNF).GDNFR alpha has more recently been designated GFR alpha -1. Species Crossreactivity: Human, mouse, rat
Purity/Purification
Highly Purified
Purified IgG prepared by ion exchange chromatography.
Form/Format
Supplied as a liquid in PBS with 0.02% sodium azide.
Immunogen
Peptide from C terminus of human GDNFR alpha.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Other Notes
Small volumes of anti-Gfra1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-Gfra1 antibody
Applications Tested/Suitable for anti-Gfra1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Gfra1 antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1:500-1:1000
Immunohistochemistry: paraffin; requires antigen retrieval with sodium citrate buffer, pH 6.0.
Optimal working dilutions to be determined by researcher.
NCBI/Uniprot data below describe general gene information for Gfra1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
51,650 Da[Similar Products]
NCBI Official Full Name
GDNF family receptor alpha-1
NCBI Official Synonym Full Names
GDNF family receptor alpha 1
NCBI Official Symbol
Gfra1  [Similar Products]
NCBI Protein Information
GDNF family receptor alpha-1; GDNFR-alpha; GFR-alpha-1; RET ligand 1; GDNFR-alpha-1; GDNF receptor alpha; GDNF receptor alpha-1; TGF-beta-related neurotrophic factor receptor 1; Glial cell line-derived neurotrophic factor receptor alpha; glial cell line derived neurotrophic factor family receptor alpha 1
UniProt Protein Name
GDNF family receptor alpha-1
UniProt Synonym Protein Names
RET ligand 1; TGF-beta-related neurotrophic factor receptor 1
Protein Family
UniProt Gene Name
Gfra1  [Similar Products]
UniProt Synonym Gene Names
Gdnfra; Retl1; Trnr1  [Similar Products]
UniProt Entry Name
GFRA1_RAT
NCBI Summary for Gfra1
binds glial cell line-derived neurotrophic factor (GDNF) and mediates Ret protein-tyrosine kinase receptor phosphorylation and activation [RGD]
UniProt Comments for Gfra1
GFRA1: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, GPI anchor

Cellular Component: extracellular space; cell soma; axon; plasma membrane; receptor complex; external side of plasma membrane

Molecular Function: integrin binding; protein binding; receptor activity

Biological Process: neuron differentiation; nervous system development; cell migration; male gonad development; kidney development; neurite development; aging
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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