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anti-Gfra2 antibody :: Rabbit GFRa2 Polyclonal Antibody

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Catalog # MBS615826
Unit / Price
  0.1 mg  /  $570 +1 FREE 8GB USB
anti-Gfra2 antibody
Product Name

GFRa2, Polyclonal Antibody

Popular Item
Also Known As

GFRa2 (GFRalpha2, Neurturin Receptor)

Product Synonym Names
Anti -GFRa2 (GFRalpha2, Neurturin Receptor)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 14; NC_000080.5 (71289937..71379645). Location: 14; 14 D3-E1
3D Structure
ModBase 3D Structure for Q3UUD8
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes human GFRa2. Species Crossreactivity: mouse, rat.
Purity/Purification
Highly Purified
Purified by ion exchange chromatography.
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Immunogen
Synthetic peptide from C-terminus of human GFRa2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-Gfra2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Gfra2 antibody
Neurturin is a member of the GDNF family and has an important role in the control of vertebrate neuron survival and differentiation. GFRa2 is a receptor for neurturin. It mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It is also able to mediate GDNF signaling through the RET tyrosine kinase receptor. GRFa2 is a 52kD glycoprotein and is a GPI-linked cell surface receptor.
Applications Tested/Suitable for anti-Gfra2 antibody
Western Blot (WB)
Application Notes for anti-Gfra2 antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000
NCBI/Uniprot data below describe general gene information for Gfra2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
51,727 Da[Similar Products]
NCBI Official Full Name
GDNF family receptor alpha-2
NCBI Official Synonym Full Names
glial cell line derived neurotrophic factor family receptor alpha 2
NCBI Official Symbol
Gfra2  [Similar Products]
NCBI Official Synonym Symbols
Gfra2
  [Similar Products]
NCBI Protein Information
GDNF family receptor alpha-2; GDNFR-beta; NTNR-alpha; GFR alpha 2; GFR alpha-2; GFR-alpha-2; NRTNR-alpha; GDNFR-alpha-2; GDNF receptor beta; GDNF receptor alpha-2; neurturin receptor alpha; TGF-beta-related neurotrophic factor receptor 2
UniProt Protein Name
Glial cell line derived neurotrophic factor family receptor alpha 2
Protein Family
UniProt Gene Name
Gfra2  [Similar Products]
UniProt Entry Name
Q3UUD8_MOUSE
NCBI Summary for Gfra2
The protein encoded by this gene is part of the receptor complex that transduces glial cell-derived neurotrophic factor and neurturin signals by mediating autophosphorylation and activation of the RET receptor. Mice lacking this protein are viable and fertile but display growth retardation attributed to impaired salivary and pancreatic secretion and innervation deficits in the intestinal tract. In addition, knockout mice display neural defects including a failure to initiate outgrowth of dorsal ganglion root neurons, demonstrating a requirement in neuronal differentiation of these cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
UniProt Comments for Gfra2
GFRA2: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor

Cellular Component: membrane; plasma membrane

Molecular Function: receptor activity; glial cell line-derived neurotrophic factor receptor activity

Biological Process: nervous system development; cytokine and chemokine mediated signaling pathway; negative regulation of protein amino acid autophosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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