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anti-GRIA4 antibody :: Rabbit GLUR4 Polyclonal Antibody

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Catalog # MBS127641
Unit / Price
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  0.05 mL  /  $230 +1 FREE 8GB USB
  0.1 mL  /  $305 +1 FREE 8GB USB
  0.2 mL  /  $460 +1 FREE 8GB USB
Western Blot (WB)
Product Name

GLUR4 (GRIA4), Polyclonal Antibody

Full Product Name

GLUR4 Polyclonal Antibody

Product Synonym Names
GRIA4 ; GLUR4; GLURD; GluA4; GLUR4C
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_000011.9 (105480800..105852819). Location: 11q22
OMIM
138246
3D Structure
ModBase 3D Structure for P48058
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
A synthetic peptide of human GLUR4
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C or -80 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-GRIA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GRIA4 antibody
AMPA(alphaamino3hydroxy5methyl4isoxazolepropionic acid), kainite, and NMDA(NmethylDaspartate) receptors are the three main families of ionotropic glutamategated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 14), which assemble as homoor heterotetramers to mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization, and plasticity (1). AMPARs that lack GluR 2 are permeable to calcium, in contrast to GluR 2containing AMPARs (2). Posttranscriptional modifications (alternative splicing, nuclear RNA editing) and posttranslational modifications (glycosylation, phosphorylation) result in a very large number of permutations, finetuning the kinetic properties of AMPARs. Research studies have implicated activity changes in AMPARs in a variety of diseases including Alzheimer's, amyotrophic lateral sclerosis (ALS), stroke, and epilepsy (1). GluR 4 containing AMPA receptors are found in synapses and GluR 4 delivery to synapses and cell surface expression is mediated through phosphorylation of Ser842 by PKA or PKC (3).
Applications Tested/Suitable for anti-GRIA4 antibody
Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-GRIA4 antibody
Western Blot (WB): 1:500-1:2000
Flow Cytometry (FC/FACS): 1:20-1:100

Western Blot (WB) of anti-GRIA4 antibody
Western blot analysis of extracts of various cell lines, using GRIA4 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 5s.
anti-GRIA4 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for GRIA4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
glutamate receptor 4 isoform 1
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, AMPA 4
NCBI Official Symbol
GRIA4  [Similar Products]
NCBI Official Synonym Symbols
GLUR4; GLURD; GluA4; GLUR4C
  [Similar Products]
NCBI Protein Information
glutamate receptor 4; gluR-4; gluR-D; AMPA-selective glutamate receptor 4; glutamate receptor, ionotrophic, AMPA 4
UniProt Protein Name
Glutamate receptor 4
UniProt Synonym Protein Names
AMPA-selective glutamate receptor 4; GluR-D; Glutamate receptor ionotropic, AMPA 4
Protein Family
UniProt Gene Name
GRIA4  [Similar Products]
UniProt Synonym Gene Names
GLUR4; GluR-4; GluR4; GluA4  [Similar Products]
UniProt Entry Name
GRIA4_HUMAN
Product References and Citations for anti-GRIA4 antibody
1. Palmer, C.L. et al. (2005) Pharmacol Rev 57, 25377. 2. CullCandy, S. et al. (2006) Curr Opin Neurobiol 16, 28897. 3. Gomes, A.R. et al. (2007) Traffic 8, 259269.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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