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anti-GNA11 antibody :: Rabbit GNA11 Polyclonal Antibody

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Catalog # MBS9607720
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Product Name

GNA11, Polyclonal Antibody

Popular Item
Full Product Name

GNA11 Antibody

Product Synonym Names
G alpha 11; G alpha q; G protein subunit alpha 11; GAQ; GNA 11; GNA11; GNAQ; Guanine nucleotide binding protein (G protein) alpha 11 (Gq class); Guanine nucleotide binding protein (G protein) alpha 11; Guanine nucleotide binding protein (G protein) q polypeptide; Guanine nucleotide binding protein alpha q; Guanine nucleotide binding protein G(q) subunit alpha; Guanine nucleotide binding protein G(y) subunit alpha; Guanine nucleotide binding protein Gq class GNA11; Guanine nucleotide binding protein subunit alpha 11
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P29992
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
GNA11 antibody detects endogenous levels of total GNA11
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human GNA11
Subcellular Location
Cell Membrane
Tissue Specificity
Expressed in testis.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-GNA11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GNA11 antibody
Description: Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of alpha, beta and gamma subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Galpha subunits have been classified into four families, Galpha(s), Galpha(i/o), Galpha(q) and Galpha(12), based on structural and functional similarities (1, 2). Phosphorylation of Tyr356 of Galpha(q)/Galpha(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Galpha with receptors and abolishes ligand-induced IP3 formation (3).
Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.
Subunit Structure: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22. Interacts with NTSR1.
Post-translational Modifications: (Microbial infection) Deamidated at Gln-209 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.
Similarity: Belongs to the G-alpha family. G(q) subfamily.
Applications Tested/Suitable for anti-GNA11 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-GNA11 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Western Blot (WB) of anti-GNA11 antibody
Western blot analysis of extracts from c476, using GNA11 Antibody. Lane 1 was treated with the blocking peptide.
anti-GNA11 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-GNA11 antibody
Western blot analysis of extracts from mouse brain, using GNA11 Antibody. Lane 1 was treated with the blocking peptide.
anti-GNA11 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-GNA11 antibody
MBS9607720 at 1/100 staining Human liver cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
anti-GNA11 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-GNA11 antibody
Western blot analysis of extracts of Leiomyosarcoma tissue, using GNA11antibody. The lane on the left is treated with the antigen-specific peptide.
anti-GNA11 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for GNA11. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 42 kDa
Predicted: 43 kDa
NCBI Official Full Name
guanine nucleotide-binding protein subunit alpha-11
NCBI Official Synonym Full Names
G protein subunit alpha 11
NCBI Official Symbol
GNA11  [Similar Products]
NCBI Official Synonym Symbols
FBH; FBH2; FHH2; HHC2; GNA-11; HYPOC2
  [Similar Products]
NCBI Protein Information
guanine nucleotide-binding protein subunit alpha-11
UniProt Protein Name
Guanine nucleotide-binding protein subunit alpha-11
UniProt Synonym Protein Names
Guanine nucleotide-binding protein G(y) subunit alpha
UniProt Gene Name
GNA11  [Similar Products]
UniProt Synonym Gene Names
GA11; G alpha-11; G-protein subunit alpha-11  [Similar Products]
NCBI Summary for GNA11
The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]
UniProt Comments for GNA11
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-GNA11 antibody
 Reference Product  PubMed Publications
 EDNRB antibody  >1 publications with GNA11 and EDNRB
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