AAH07211.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,571 Da
NCBI Official Full Name
GPR177 protein, partial
NCBI Official Synonym Full Names
wntless Wnt ligand secretion mediator
NCBI Official Synonym Symbols
EVI; MRP; GPR177; mig-14; C1orf139 [Similar Products]
NCBI Protein Information
protein wntless homolog; G protein-coupled receptor 177; integral membrane protein GPR177; protein evenness interrupted homolog; putative NF-kappa-B-activating protein 373; putative NFkB activating protein 373
UniProt Protein Name
Protein wntless homolog
UniProt Synonym Protein Names
Integral membrane protein GPR177; Protein evenness interrupted homolog; EVI; Putative NF-kappa-B-activating protein 373
UniProt Synonym Gene Names
UniProt Entry Name
WLS_HUMAN
UniProt Comments for GPR177
GPR177: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development. Belongs to the wntless family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: Golgi membrane; dendrite cytoplasm; cytoplasmic vesicle membrane; early endosome membrane; integral to membrane; plasma membrane
Molecular Function: Wnt-protein binding; protein binding; signal transducer activity; mu-type opioid receptor binding
Biological Process: Wnt receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; mesoderm formation; anterior/posterior axis specification
Research Articles on GPR177
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Pathways associated with anti-GPR177 antibody
Diseases associated with anti-GPR177 antibody
Organs/Tissues associated with anti-GPR177 antibody
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