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anti-GPR44 antibody :: Rabbit GPR44 / CRTH2 Polyclonal Antibody

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Catalog # MBS242319
Unit / Price
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  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

GPR44 / CRTH2, Polyclonal Antibody

Popular Item
Full Product Name

Rabbit Polyclonal to Human GPR44 / CRTH2

Product Synonym Names
Anti-GPR44 / CRTH2 Antibody (N-Terminus) IHC-plus; PTGDR2; CD294; CRTH2; CD294 antigen; DP2; DL1R; G protein-coupled receptor 44; G-protein coupled receptor 44; HCRTH2; DP2 prostaglandin receptor; GPR44; Prostaglandin D2 receptor 2; Human GPR44; CRTH2
Product Synonym Gene Name
CRTH2; PTGDR2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
604837
3D Structure
ModBase 3D Structure for Q9Y5Y4
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
18 amino acid peptide from near the amino terminus of human CRTH2.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide from human GPR44 / CRTH2.
Immunogen Type
Synthetic peptide
Immunogen
GPR44 / CRTH2 antibody was raised against synthetic peptide from human GPR44 / CRTH2.
Antigen Modification
N-Terminus
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Other Notes
Small volumes of anti-GPR44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GPR44 antibody
GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells.
Applications Tested/Suitable for anti-GPR44 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-GPR44 antibody
ELISA, IHC-P (5 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-GPR44 antibody
Anti-GPR44 / CRTH2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-GPR44 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-GPR44 antibody
Anti-GPR44 / CRTH2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-GPR44 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-GPR44 antibody
Anti-GPR44 / CRTH2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-GPR44 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-GPR44 antibody
Immunofluorescence of CRTH2 in Human Heart cells with CRTH2 antibody at 20 ug/ml.
anti-GPR44 antibody Immunofluorescence (IF) image
Western Blot (WB) of anti-GPR44 antibody
Western blot of CRTH2 in Jurkat cell lysate with at 1 ug/ml in (A) the absence and (B) presence of blocking peptide.
anti-GPR44 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for GPR44. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,268 Da
NCBI Official Full Name
prostaglandin D2 receptor 2
NCBI Official Synonym Full Names
prostaglandin D2 receptor 2
NCBI Official Symbol
PTGDR2  [Similar Products]
NCBI Official Synonym Symbols
DP2; DL1R; CD294; CRTH2; GPR44
  [Similar Products]
NCBI Protein Information
prostaglandin D2 receptor 2; G protein-coupled receptor 44; G-protein coupled receptor 44; putative G-protein coupled receptor 44; chemoattractant receptor-homologous molecule expressed on TH2 cells; chemoattractant receptor homologous molecule expressed on T helper type 2 cells
UniProt Protein Name
Prostaglandin D2 receptor 2
UniProt Synonym Protein Names
Chemoattractant receptor-homologous molecule expressed on Th2 cells; G-protein coupled receptor 44; CD_antigen: CD294
UniProt Gene Name
PTGDR2  [Similar Products]
UniProt Synonym Gene Names
CRTH2; DL1R; GPR44  [Similar Products]
UniProt Entry Name
PD2R2_HUMAN
NCBI Summary for GPR44
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
UniProt Comments for GPR44
GPR44: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12-q13.3

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; neuropeptide binding; prostaglandin F receptor activity; prostaglandin J receptor activity; prostaglandin D receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; calcium-mediated signaling; immune response; G-protein signaling, adenylate cyclase inhibiting pathway; chemotaxis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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