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anti-GRIN1 antibody :: Rabbit GRIN1 / NMDAR1 Polyclonal Antibody

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Catalog # MBS242755
Unit / Price
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  0.05 mL  /  $530 +1 FREE 8GB USB
Product Name

GRIN1 / NMDAR1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal (IgG) to Human GRIN1 / NMDAR1

Product Synonym Names
Anti-GRIN1 / NMDAR1 Antibody (aa864-913) IHC-plus; GRIN1; GluN1; NMDAR1; NR1; MRD8; NMD-R1; NMDA receptor A1; NMDA1; NR1a; GluR zeta 1; Human GRIN1; NMDAR1
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 614254
3D Structure
ModBase 3D Structure for Q05586
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
NMDAR1 antibody detects endogenous levels of total NMDAR1 protein.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide from human NMDAR1 (aa864-913).
Immunogen
GRIN1 / NMDAR1 antibody was raised against synthetic peptide from human NMDAR1 (aa864-913).
Antigen Modification
aa864-913
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Other Notes
Small volumes of anti-GRIN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GRIN1 antibody
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR).
Applications Tested/Suitable for anti-GRIN1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-GRIN1 antibody
ELISA (1:20000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-GRIN1 antibody
Anti-GRIN1 / NMDAR1 antibody IHC of human brain, cortex neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-GRIN1 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-GRIN1 antibody
Western blot of extracts from Jurkat cells, using NMDAR1 antibody. The lane on the right is treated with the synthesized peptide.
anti-GRIN1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for GRIN1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
101,851 Da
NCBI Official Full Name
glutamate receptor ionotropic, NMDA 1 isoform GluN1-1a
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, N-methyl D-aspartate 1
NCBI Official Symbol
GRIN1  [Similar Products]
NCBI Official Synonym Symbols
NR1; MRD8; GluN1; NMDA1; NMD-R1; NMDAR1
  [Similar Products]
NCBI Protein Information
glutamate receptor ionotropic, NMDA 1; glutamate [NMDA] receptor subunit zeta 1; glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; N-methyl-D-aspartate receptor channel, subunit zeta-1
UniProt Protein Name
Glutamate receptor ionotropic, NMDA 1
UniProt Synonym Protein Names
Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1
UniProt Gene Name
GRIN1  [Similar Products]
UniProt Synonym Gene Names
NMDAR1; GluN1; NMD-R1  [Similar Products]
UniProt Entry Name
NMDZ1_HUMAN
NCBI Summary for GRIN1
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for GRIN1
NMDAR1: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. Three alternatively-spliced isoforms have been described.

Protein type: Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass; Channel, calcium

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: neuron projection; cell surface; integral to plasma membrane; endoplasmic reticulum; postsynaptic density; dendrite; dendritic spine; terminal button; excitatory synapse; N-methyl-D-aspartate selective glutamate receptor complex; postsynaptic membrane; synaptic vesicle; plasma membrane; synapse; cell junction

Molecular Function: voltage-gated cation channel activity; calmodulin binding; neurotransmitter binding; protein binding; glutamate receptor binding; enzyme binding; extracellular-glutamate-gated ion channel activity; glutamate binding; protein heterodimerization activity; calcium channel activity; N-methyl-D-aspartate selective glutamate receptor activity; glycine binding; calcium ion binding

Biological Process: regulation of long-term neuronal synaptic plasticity; axon guidance; male mating behavior; prepulse inhibition; adult locomotory behavior; positive regulation of apoptosis; regulation of dendrite morphogenesis; rhythmic process; response to morphine; regulation of axonogenesis; sensory perception of pain; calcium ion homeostasis; synaptic transmission; regulation of respiratory gaseous exchange; conditioned taste aversion; ephrin receptor signaling pathway; visual learning; negative regulation of neuron apoptosis; protein tetramerization; cation transport; synaptic transmission, glutamatergic; response to amphetamine; social behavior; respiratory gaseous exchange; pons maturation; cellular calcium ion homeostasis; regulation of membrane potential; response to ethanol; long-term memory; regulation of synaptogenesis; suckling behavior; olfactory learning; propylene metabolic process; ionotropic glutamate receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; regulation of excitatory postsynaptic membrane potential; response to calcium ion

Disease: Mental Retardation, Autosomal Dominant 8
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Organs/Tissues associated with anti-GRIN1 antibody
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