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anti-HECTD1 antibody :: Rabbit HECTD1 Polyclonal Antibody

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Catalog # MBS9609795
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Product Name

HECTD1, Polyclonal Antibody

Popular Item
Also Known As

HECTD1 Antibody

Product Synonym Names
E3 ligase for inhibin receptor; E3 ubiquitin protein ligase HECTD1; E3 ubiquitin-protein ligase HECTD1; EULIR; HECD1_HUMAN; HECT domain containing protein 1; HECT domain-containing protein 1; HECTD1; KIAA1131
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
2610
3D Structure
ModBase 3D Structure for Q9ULT8
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
HECTD1 antibody detects endogenous levels of total HECTD1
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human HECTD1
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-HECTD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HECTD1 antibody
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure.
Subunit Structure: Interacts with IGSF1 (PubMed:12421765). Interacts (via N-terminus) with HSP90AA1 (By similarity).
Similarity: Belongs to the UPL family. K-HECT subfamily.
Applications Tested/Suitable for anti-HECTD1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-HECTD1 antibody
WB: 1:1000-3000

Western Blot (WB) of anti-HECTD1 antibody
Western blot analysis of extracts from rat brain, using HECTD1 Antibody.
anti-HECTD1 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-HECTD1 antibody
Western blot analysis of HECTD1 using COS7 whole cell lysates
anti-HECTD1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for HECTD1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 289 kDa
Predicted: 290 kDa
NCBI Official Full Name
E3 ubiquitin-protein ligase HECTD1
NCBI Official Synonym Full Names
HECT domain E3 ubiquitin protein ligase 1
NCBI Official Symbol
HECTD1  [Similar Products]
NCBI Official Synonym Symbols
EULIR
  [Similar Products]
NCBI Protein Information
E3 ubiquitin-protein ligase HECTD1
UniProt Protein Name
E3 ubiquitin-protein ligase HECTD1
UniProt Synonym Protein Names
E3 ligase for inhibin receptor; EULIR; HECT domain-containing protein 1; HECT-type E3 ubiquitin transferase HECTD1
UniProt Gene Name
HECTD1  [Similar Products]
UniProt Synonym Gene Names
KIAA1131  [Similar Products]
UniProt Comments for HECTD1
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells may impair their emigration and may be essential for the correct development of the cranial neural folds and neural tube closure.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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