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anti-HCK antibody :: Rabbit hemopoietic cell kinase Polyclonal Antibody

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Catalog # MBS710033
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-HCK antibody
Product Name

hemopoietic cell kinase (HCK), Polyclonal Antibody

Full Product Name

Rabbit anti-human hemopoietic cell kinase polyclonal Antibody

Product Synonym Names
hemopoietic cell kinase; HCK; JTK9
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
142370
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human HCK
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-72 / sc-11401
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-HCK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-HCK antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for HCK. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,529 Da[Similar Products]
NCBI Official Full Name
Hemopoietic cell kinase
NCBI Official Synonym Full Names
HCK proto-oncogene, Src family tyrosine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
JTK9; p59Hck; p61Hck
  [Similar Products]
NCBI Protein Information
tyrosine-protein kinase HCK; p59-HCK/p60-HCK; hemopoietic cell kinase; hematopoietic cell kinase
UniProt Protein Name
Tyrosine-protein kinase HCK
UniProt Synonym Protein Names
Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck
Protein Family
UniProt Gene Name
UniProt Entry Name
HCK_HUMAN
NCBI Summary for HCK
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]
UniProt Comments for HCK
Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization.

Protein type: Oncoprotein; Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Src family

Chromosomal Location of Human Ortholog: 20q11-q12

Cellular Component: Golgi apparatus; extrinsic to internal side of plasma membrane; transport vesicle; focal adhesion; cell projection; lysosome; actin filament; caveola; nucleus; cytosol

Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: integrin-mediated signaling pathway; respiratory burst after phagocytosis; peptidyl-tyrosine phosphorylation; viral reproduction; cytokine and chemokine mediated signaling pathway; protein amino acid autophosphorylation; regulation of phagocytosis; protein amino acid phosphorylation; regulation of defense response to virus by virus; regulation of cell shape; leukocyte migration during immune response; positive regulation of actin filament polymerization; regulation of transcription factor activity; leukocyte degranulation; positive regulation of cell proliferation; regulation of inflammatory response; lipopolysaccharide-mediated signaling pathway; innate immune response; mesoderm development; inflammatory response; cell adhesion; innate immune response-activating signal transduction; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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