NP_002106.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
99,025 Da
NCBI Official Full Name
hexokinase-3
NCBI Official Synonym Full Names
hexokinase 3 (white cell)
NCBI Official Synonym Symbols
NCBI Protein Information
hexokinase-3; ATP:D-hexose 6-phosphotransferase; HK III; hexokinase type III
UniProt Protein Name
Hexokinase-3
UniProt Synonym Protein Names
Hexokinase type III; HK III
UniProt Synonym Gene Names
UniProt Entry Name
HXK3_HUMAN
NCBI Summary for HK3
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]
UniProt Comments for HK3
HK3: a glycolytic enzyme that catalyzes the reaction ATP + D-hexose = ADP + D-hexose 6-phosphate. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. An allosteric enzyme inhibited by its product glucose-6-phosphate (Glc-6-P). Acts as a ""glucose sensor"" by trapping glucose inside the cell by catalyzing its phosphorylation to produce Glc-6-P. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).
Protein type: EC 2.7.1.1; Transferase; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Enzyme, cellular metabolism; Kinase, other; Carbohydrate Metabolism - glycolysis and gluconeogenesis
Chromosomal Location of Human Ortholog: 5q35.2
Cellular Component: protein complex; mitochondrion; cytosol
Molecular Function: hexokinase activity; enzyme binding; mannokinase activity; hormone binding; fructokinase activity; glucokinase activity; ATP binding
Biological Process: hexose metabolic process; glycolysis; hexose transport; carbohydrate metabolic process; glucose 6-phosphate metabolic process; carbohydrate phosphorylation; cell glucose homeostasis; pathogenesis; glucose transport; transmembrane transport
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Products associated withanti-HK3 antibody
Pathways associated with anti-HK3 antibody
Diseases associated with anti-HK3 antibody
| Disease Name |
Pubmed Publications |
| Carcinoma Antibodies |
>10 publications with HK3 and Carcinoma |
| Hyperplasia Antibodies |
>7 publications with HK3 and Hyperplasia |
| Skin Neoplasms Antibodies |
>4 publications with HK3 and Skin Neoplasms |
| Liver Neoplasms Antibodies |
>2 publications with HK3 and Liver Neoplasms |
| Carcinoma, Hepatocellular Antibodies |
>2 publications with HK3 and Carcinoma, Hepatocellular |
| Leukemia, Promyelocytic, Acute Antibodies |
>2 publications with HK3 and Leukemia, Promyelocytic, Acute |
| Liver Diseases Antibodies |
>2 publications with HK3 and Liver Diseases |
| Neoplasms, Experimental Antibodies |
>1 publications with HK3 and Neoplasms, Experimental |
| Carcinoma, Squamous Cell Antibodies |
>1 publications with HK3 and Carcinoma, Squamous Cell |
| Cell Transformation, Neoplastic Antibodies |
>1 publications with HK3 and Cell Transformation, Neoplastic |
Organs/Tissues associated with anti-HK3 antibody
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