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anti-HLA-A antibody :: Rabbit HLA-A Polyclonal Antibody

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Catalog # MBS2522582
Unit / Price
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  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

HLA-A, Polyclonal Antibody

Popular Item
Full Product Name

HLA-A Antibody

Product Synonym Names
FLJ26655; HLAA
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
142800
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
1mg/mL (lot specific)
Immunogen
Recombinant protein of human HLA-A
Observed Molecular Weight: 41kDa
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-HLA-A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HLA-A antibody
Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21. 3). There are two classes of HLA antigens: class I (HLA-A, B and C) and class II (HLA-D). This class I molecules are polymorphic membrane glycoproteins composed of a heavy (alpha) chain (44 kDa) which is encoded by a HLA class I gene (HLA-A, B or C), and beta2-microglobulin light (beta) chain (12 kDa). They are involved in the presentation of foreign antigens to the immune system. (PMID: 667938; 3375250)
Applications Tested/Suitable for anti-HLA-A antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Western Blot (WB) of anti-HLA-A antibody
Western blot analysis of extracts of various cell lines, using HLA-A antibody.
anti-HLA-A antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-HLA-A antibody
Immunohistochemistry of paraffin-embedded human endometrial cancer using HLA-A antibody at dilution of 1:500 (200x lens).
anti-HLA-A antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-HLA-A antibody
Immunohistochemistry of paraffin-embedded mouse kidney using HLA-A antibody at dilution of 1:500 (200x lens).
anti-HLA-A antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-HLA-A antibody
Immunofluorescence analysis of U2OS cell using HLA-A antibody. Blue: DAPI for nuclear staining
anti-HLA-A antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for HLA-A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,909 Da
NCBI Official Full Name
HLA-A
NCBI Official Synonym Full Names
major histocompatibility complex, class I, A
NCBI Official Symbol
HLA-A  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
HLA class I histocompatibility antigen, A-1 alpha chain; MHC class I antigen HLA-A heavy chain; antigen presenting molecule; leukocyte antigen class I-A
UniProt Protein Name
HLA class I histocompatibility antigen, A-68 alpha chain
UniProt Synonym Protein Names
Aw-68; HLA class I histocompatibility antigen, A-28 alpha chain; MHC class I antigen A*68
UniProt Gene Name
HLA-A  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
1A68_HUMAN
NCBI Summary for HLA-A
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for HLA-A
HLAA: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; Golgi apparatus; phagocytic vesicle membrane; cell surface; membrane; early endosome membrane; integral to plasma membrane; endoplasmic reticulum; plasma membrane; MHC class I protein complex; Golgi medial cisterna

Molecular Function: protein binding; peptide antigen binding; beta-2-microglobulin binding; T cell receptor binding; TAP binding; receptor binding

Biological Process: regulation of immune response; viral reproduction; detection of bacterium; positive regulation of T cell mediated cytotoxicity; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; protection from natural killer cell mediated cytotoxicity; positive regulation of interferon-gamma production; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response

Disease: Severe Cutaneous Adverse Reaction, Susceptibility To
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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