NP_001276839.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 50 kDa Predicted: 51 kDa
NCBI Official Full Name
isocitrate dehydrogenase
NCBI Official Synonym Full Names
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
NCBI Official Synonym Symbols
IDH; IDP; IDHM; IDPM; ICD-M; D2HGA2; mNADP-IDH [Similar Products]
NCBI Protein Information
isocitrate dehydrogenase [NADP], mitochondrial
UniProt Protein Name
Isocitrate dehydrogenase [NADP], mitochondrial
UniProt Synonym Protein Names
ICD-M; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase
UniProt Synonym Gene Names
NCBI Summary for IDH2
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
UniProt Comments for IDH2
Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
Research Articles on IDH2
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Products associated with anti-IDH2 antibody
Pathways associated with anti-IDH2 antibody
Diseases associated with anti-IDH2 antibody
Disease Name |
Pubmed Publications |
Leukemia, Myeloid, Acute Antibodies |
>183 publications with IDH2 and Leukemia, Myeloid, Acute |
Nervous System Diseases Antibodies |
>156 publications with IDH2 and Nervous System Diseases |
Brain Diseases Antibodies |
>150 publications with IDH2 and Brain Diseases |
Oligodendroglioma Antibodies |
>38 publications with IDH2 and Oligodendroglioma |
Cell Transformation, Neoplastic Antibodies |
>29 publications with IDH2 and Cell Transformation, Neoplastic |
Cholangiocarcinoma Antibodies |
>19 publications with IDH2 and Cholangiocarcinoma |
Neoplasms, Experimental Antibodies |
>12 publications with IDH2 and Neoplasms, Experimental |
Liver Neoplasms Antibodies |
>12 publications with IDH2 and Liver Neoplasms |
Anemia Antibodies |
>10 publications with IDH2 and Anemia |
Lymphoma, T-Cell, Peripheral Antibodies |
>8 publications with IDH2 and Lymphoma, T-Cell, Peripheral |
Organs/Tissues associated with anti-IDH2 antibody
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