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anti-IGF2BP1 antibody :: Rabbit IGF2BP1 Polyclonal Antibody

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Catalog # MBS2524880
Unit / Price
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  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

IGF2BP1, Polyclonal Antibody

Popular Item
Full Product Name

IGF2BP1 Polyclonal Antibody

Product Synonym Names
IMP1, ZBP1, CRDBP, IMP-1, CRD-BP, VICKZ1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
608288
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
1mg/mL (lot specific)
Immunogen
Synthetic peptide of human IGF2BP1
Calculated Molecular Weight: 63kDa
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-IGF2BP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IGF2BP1 antibody
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-IGF2BP1 antibody
Applications Tested/Suitable for anti-IGF2BP1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-IGF2BP1 antibody
WB: 1:500-1:2000
IHC: 1:10-1:50

Western Blot (WB) of anti-IGF2BP1 antibody
Western Blot analysis of Human fetal lung tissue using IGF2BP1 Polyclonal Antibody at dilution of 1:500
anti-IGF2BP1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-IGF2BP1 antibody
Immunohistochemistry of paraffin-embedded Human lung cancer using IGF2BP1 Polyclonal Antibody at dilution of 1:25
anti-IGF2BP1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for IGF2BP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,598 Da
NCBI Official Full Name
insulin-like growth factor 2 mRNA-binding protein 1 isoform 1
NCBI Official Synonym Full Names
insulin-like growth factor 2 mRNA binding protein 1
NCBI Official Symbol
IGF2BP1  [Similar Products]
NCBI Official Synonym Symbols
IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1
  [Similar Products]
NCBI Protein Information
insulin-like growth factor 2 mRNA-binding protein 1; IGF-II mRNA-binding protein 1; IGF2 mRNA-binding protein 1; VICKZ family member 1; ZBP-1; coding region determinant-binding protein; zipcode-binding protein 1
UniProt Protein Name
Insulin-like growth factor 2 mRNA-binding protein 1
UniProt Synonym Protein Names
Coding region determinant-binding protein; CRD-BP; IGF-II mRNA-binding protein 1; VICKZ family member 1; Zipcode-binding protein 1; ZBP-1
UniProt Gene Name
IGF2BP1  [Similar Products]
UniProt Synonym Gene Names
CRDBP; VICKZ1; ZBP1; IGF2 mRNA-binding protein 1; IMP-1; IMP1; CRD-BP; ZBP-1  [Similar Products]
UniProt Entry Name
IF2B1_HUMAN
NCBI Summary for IGF2BP1
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Comments for IGF2BP1
IGF2BP1: a conserved trans-acting factor that can control translation of specific mRNAs in vivo. Contains four K homology (KH) domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the target mRNAs and repressing translation. Target mRNAs include those encoding beta-actin and insulin-like growth factor 2 (IGF2). Tyrosine phosphorylation apparently abolishes translational repression of actin expression by decreasing its binding beta-actin mRNA. May have a role in progression of ovarian cancer. Contains nuclear export signals within the RNA-binding KH2 and KH4 domains. Aberrant expression may interfere with c-myc regulation.

Protein type: Translation; RNA-binding

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: growth cone; lamellipodium; axon; perinuclear region of cytoplasm; stress granule; cytoplasm; dendritic spine; cytosol; ribonucleoprotein complex; nucleus; filopodium

Molecular Function: mRNA binding; protein binding; mRNA 3'-UTR binding; nucleotide binding; translation regulator activity; mRNA 5'-UTR binding

Biological Process: mRNA transport; negative regulation of translation; gene expression; regulation of cytokine biosynthetic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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