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anti-IKBKG antibody :: Rabbit IKK gamma Polyclonal Antibody

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Catalog # MBS150068
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

IKK gamma (IKBKG), Polyclonal Antibody

Also Known As

IKK gamma Antibody

Product Synonym Names
IKK gamma; IP; IP1; IP2; FIP3; IPD2; NEMO; FIP-3; Fip3p; AMCBX1; ZC2HC9; IKK-gamma; NF-kappa-B essential modulator; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1994
OMIM
phenotype 308300
3D Structure
ModBase 3D Structure for Q9Y6K9
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
IKK gamma has no cross response to IKK alpha or IKK beta.
Purity/Purification
IKK gamma Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Conjugate
Unconjugated
Immunogen
IKK gamma antibody was raised against a 17 amino acid peptide near the carboxy terminus of human IKK gamma.
Buffer
IKK gamma Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
IKK gamma antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-IKBKG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IKBKG antibody
IKK gamma Antibody: Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. The IκB kinase (IKKα and IKKβ) phosphorylates IkB and mediates NF-κB activation. A novel molecule in the IKK complex was recently identified and termed IKKγ/NEMO/FIP3/IKKAP1. IKKγ interacts with IKKβ and is required for the activation of IKK complex and NF-κB by LPS, PMA, TNF, and IL-1 stimulation. FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-κB activation.
Applications Tested/Suitable for anti-IKBKG antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-IKBKG antibody
IKK gamma antibody can be used for detection of IKK gamma by Western blot at 1 mug/mL. A 52 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 5 mug/mL.

Western Blot (WB) of anti-IKBKG antibody
Western blot analysis of IKK gamma in HeLa whole cell lysate with IKK gamma antibody at 1 μg/mL.
anti-IKBKG antibody Western Blot (WB) (WB) image
Immunocytochemistry (ICC) of anti-IKBKG antibody
Immunocytochemistry of IKK gamma in HeLa cells with IKK gamma antibody at 5 μg/mL.
anti-IKBKG antibody Immunocytochemistry (ICC) (ICC) image
NCBI/Uniprot data below describe general gene information for IKBKG. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52 kDa
NCBI Official Full Name
Homo sapiens IkB kinase gamma subunit (IKK-gamma) mRNA, complete cds
NCBI Official Synonym Full Names
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
NCBI Official Symbol
IKBKG  [Similar Products]
NCBI Official Synonym Symbols
IP; IP1; IP2; FIP3; IPD2; NEMO; FIP-3; Fip3p; IMD33; AMCBX1; ZC2HC9; IKK-gamma
  [Similar Products]
NCBI Protein Information
NF-kappa-B essential modulator; IKKG; IKKAP1; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma
UniProt Protein Name
NF-kappa-B essential modulator
UniProt Synonym Protein Names
FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifier
UniProt Gene Name
IKBKG  [Similar Products]
UniProt Synonym Gene Names
FIP3; NEMO; NEMO; IKKAP1; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma  [Similar Products]
UniProt Entry Name
NEMO_HUMAN
NCBI Summary for IKBKG
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011]
UniProt Comments for IKBKG
IKKG: a regulatory subunit of the IKK-signalosome complex. Interacts preferentially with IKK-beta but also able to interact with IKK-alpha, IKAP, TAX, RIP and MAP3K14/NIK. Defects are the cause of familial incontinentia pigmenti type II (IP2).

Protein type: Adaptor/scaffold; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: spindle pole; cytoplasm; IkappaB kinase complex; intracellular; nucleus; cytosol; ubiquitin ligase complex

Molecular Function: protein domain specific binding; peroxisome proliferator activated receptor binding; protein binding; signal transducer activity; protein homodimerization activity; protein heterodimerization activity; ubiquitin protein ligase binding; metal ion binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; establishment of vesicle localization; viral reproduction; activation of MAPK activity; apoptosis; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; B cell homeostasis; positive regulation of interferon type I production; JNK cascade; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; response to virus; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; response to DNA damage stimulus

Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 2; Ectodermal Dysplasia, Hypohidrotic, With Immune Deficiency; Immunodeficiency Without Anhidrotic Ectodermal Dysplasia; Immunodeficiency 33; Incontinentia Pigmenti; Ectodermal Dysplasia, Anhidrotic, With Immunodeficiency, Osteopetrosis, And Lymphedema
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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