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anti-ITPR1 antibody :: Rabbit inositol 1, 4, 5-triphosphate receptor, type 1 Polyclonal Antibody

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Catalog # MBS716770
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-ITPR1 antibody
Product Name

inositol 1, 4, 5-triphosphate receptor, type 1 (ITPR1), Polyclonal Antibody

Also Known As

Rabbit anti-human inositol 1, 4, 5-triphosphate receptor, type 1 polyclonal Antibody

Product Synonym Names
inositol 1; 4; 5-triphosphate receptor; type 1; ITPR1; INSP3R1; IP3R; IP3R1; SCA15; SCA16
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
gene 606658
Species Reactivity
Human, Mouse, Rat
Antigen Affinity Purified
Human ITPR1-specific
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-26382 / sc-26381 / sc-6093 / sc-28614
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-ITPR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ITPR1 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for ITPR1. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
309,338 Da[Similar Products]
NCBI Official Full Name
inositol 1,4,5-trisphosphate receptor type 1 isoform 3
NCBI Official Synonym Full Names
inositol 1,4,5-trisphosphate receptor, type 1
NCBI Official Symbol
ITPR1  [Similar Products]
NCBI Official Synonym Symbols
ACV; CLA4; IP3R; IP3R1; SCA15; SCA16; SCA29; INSP3R1; PPP1R94
  [Similar Products]
NCBI Protein Information
inositol 1,4,5-trisphosphate receptor type 1; IP3R 1; IP3 receptor; type 1 InsP3 receptor; inositol 1,4,5-triphosphate receptor, type 1; protein phosphatase 1, regulatory subunit 94; type 1 inositol 1,4,5-trisphosphate receptor
UniProt Protein Name
Inositol 1,4,5-trisphosphate receptor type 1
UniProt Synonym Protein Names
IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
UniProt Gene Name
ITPR1  [Similar Products]
UniProt Synonym Gene Names
INSP3R1; IP3R 1; InsP3R1; Type 1 InsP3 receptor  [Similar Products]
UniProt Entry Name
NCBI Summary for ITPR1
This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
UniProt Comments for ITPR1
IP3R1: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaMKII, eventually leading to the activation of downstream apoptosis pathways. Part of a cGMP kinase signaling complex that includes alpha-actin, calponin H1, phospholamban, PKG1 and IP3R1. Widely expressed. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA prevents the ligand-induced opening of the calcium channels. Belongs to the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family. Eight alternatively spliced isoforms have been described.

Protein type: Channel, ligand-gated; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p26.1

Cellular Component: endoplasmic reticulum membrane; membrane; sarcoplasmic reticulum; endoplasmic reticulum; postsynaptic density; nucleolus; integral to membrane; nuclear inner membrane; platelet dense granule membrane; calcineurin complex

Molecular Function: protein binding; calcium ion transmembrane transporter activity; calcium channel inhibitor activity; intracellular ligand-gated calcium channel activity; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity

Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of calcium-mediated signaling; platelet activation; inositol phosphate-mediated signaling; voluntary musculoskeletal movement; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; post-embryonic development; endoplasmic reticulum calcium ion homeostasis; phospholipase C activation; calcium ion transport; release of sequestered calcium ion into cytosol; energy reserve metabolic process; response to hypoxia; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; regulation of insulin secretion
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