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anti-INPP5D antibody :: Rabbit inositol polyphosphate-5-phosphatase Polyclonal Antibody

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Catalog # MBS714285
Unit / Price
  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-INPP5D antibody
Product Name

inositol polyphosphate-5-phosphatase (INPP5D), Polyclonal Antibody

Also Known As

Rabbit anti-human inositol polyphosphate-5-phosphatase, 72 kDa polyclonal Antibody

Product Synonym Names
inositol polyphosphate-5-phosphatase; 72 kDa; INPP5E; MGC117201; PPI5PIV
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1188
OMIM
601582
3D Structure
ModBase 3D Structure for Q92835
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Immunogen
Human INPP5E
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-161086
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-INPP5D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-INPP5D antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
NCBI/Uniprot data below describe general gene information for INPP5D. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
109,294 Da[Similar Products]
NCBI Official Full Name
inositol polyphosphate 5- phosphatase
NCBI Official Synonym Full Names
inositol polyphosphate-5-phosphatase, 145kDa
NCBI Official Symbol
INPP5D  [Similar Products]
NCBI Official Synonym Symbols
SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship
  [Similar Products]
NCBI Protein Information
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; inositol polyphosphate-5-phosphatase, 145kD; SH2 domain-containing inositol 5'-phosphatase 1; signaling inositol polyphosphate phosphatase SHIP II; signaling inositol polyphosphate 5 phosphatase SIP-145
UniProt Protein Name
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
UniProt Synonym Protein Names
Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1; p150Ship; hp51CN
UniProt Gene Name
INPP5D  [Similar Products]
UniProt Synonym Gene Names
SHIP; SHIP1; SIP-145; SH2 domain-containing inositol phosphatase 1; SHIP-1; hp51CN  [Similar Products]
UniProt Entry Name
SHIP1_HUMAN
NCBI Summary for INPP5D
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
UniProt Comments for INPP5D
SHIP: an SH2-containing inositol phosphatase. A hemopoietic-specific phosphatase that regulates cell survival, growth, cell cycle arrest and apoptosis. Hydrolyzes Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3. A cytosolic protein with a SH2 domain in its N-terminus and two NPXY Shc binding motifs at its C-terminus. Upon receptor cross-linking, SHIP is first recruited to the plasma membrane by its SH2, followed by tyrosine phosphorylation on the NPXY motif. Both membrane relocalization and phosphorylation are essential for its regulatory function. Associates with SHC after cytokine stimulation.

Protein type: EC 3.1.3.86; Phosphatase, lipid; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: membrane; cytosol

Molecular Function: protein binding; inositol-polyphosphate 5-phosphatase activity; SH3 domain binding

Biological Process: inositol phosphate metabolic process; apoptosis; phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; blood coagulation; signal transduction; T cell receptor signaling pathway; leukocyte migration; phosphate metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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