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anti-IRAK3 antibody :: Rabbit IRAK-M Polyclonal Antibody

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Catalog # MBS150500
Unit / Price
  0.1 mg  /  $375 +1 FREE 8GB USB
Product Name

IRAK-M (IRAK3), Polyclonal Antibody

Popular Item
Full Product Name

IRAK-M Antibody

Product Synonym Names
IRAK-M; ASRT5; IRAKM; Interleukin-1 receptor-associated kinase 3; IL-1 receptor-associated kinase M; IRAK-3; interleukin-1 receptor-associated kinase 3
Antibody/Peptide Pairs
IRAK-M peptide (MBS152204) is used for blocking the activity of IRAK-M antibody (MBS150500)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 611064
3D Structure
ModBase 3D Structure for Q9Y616
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
IRAK-M antibody has no cross response to IRAK or IRAK2.
Purity/Purification
IRAK-M Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Conjugate
Unconjugated
Immunogen
IRAK-M antibody was raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK-M.
Buffer
IRAK-M Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
IRAK-M antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-IRAK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IRAK3 antibody
IRAK-M Antibody: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.
Applications Tested/Suitable for anti-IRAK3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-IRAK3 antibody
IRAK-M antibody can be used for detection of IRAK-M by Western blot at 1 mug/mL. A 68 kDa major band can be detected. IRAK-M antibody can also detect IRAK-M by immunohistochemistry at 2 mug/mL. For immunofluorescence start at 10 mug/mL.

Western Blot (WB) of anti-IRAK3 antibody
Western blot analysis of IRAK-M in (M) mouse spleen and (R) rat liver tissue lysates with IRAK-M antibody at 1 μg/mL.
anti-IRAK3 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-IRAK3 antibody
Immunohistochemical staining of rat liver tissue using IRAK-M antibody at 2 μg/mL.
anti-IRAK3 antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-IRAK3 antibody
Immunofluorescence of IRAK-M in Rat Liver tissue with IRAK-M antibody at 10 μg/mL.
anti-IRAK3 antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for IRAK3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68 kDa
NCBI Official Full Name
Homo sapiens IL-1 receptor-associated-kinase-M mRNA, complete cds
NCBI Official Synonym Full Names
interleukin-1 receptor-associated kinase 3
NCBI Official Symbol
IRAK3  [Similar Products]
NCBI Official Synonym Symbols
ASRT5; IRAKM
  [Similar Products]
NCBI Protein Information
interleukin-1 receptor-associated kinase 3; IRAK3; IL-1 receptor-associated kinase M
UniProt Protein Name
Interleukin-1 receptor-associated kinase 3
UniProt Synonym Protein Names
IL-1 receptor-associated kinase M; IRAK-M
UniProt Gene Name
IRAK3  [Similar Products]
UniProt Synonym Gene Names
IRAK-3; IRAK-M  [Similar Products]
UniProt Entry Name
IRAK3_HUMAN
NCBI Summary for IRAK3
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
UniProt Comments for IRAK3
IRAK3: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, TKL; EC 2.7.11.1; TKL group; IRAK family

Chromosomal Location of Human Ortholog: 12q14.3

Cellular Component: interleukin-1 receptor complex; cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein homodimerization activity; protein heterodimerization activity; magnesium ion binding; ATP binding

Biological Process: negative regulation of MAP kinase activity; regulation of protein complex disassembly; negative regulation of interleukin-12 production; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; response to virus; response to lipopolysaccharide; negative regulation of tumor necrosis factor production; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; response to exogenous dsRNA; negative regulation of innate immune response; inhibition of NF-kappaB transcription factor; response to peptidoglycan; negative regulation of toll-like receptor signaling pathway; toll-like receptor signaling pathway; negative regulation of interleukin-6 production; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of protein catabolic process; negative regulation of protein complex disassembly

Disease: Asthma-related Traits, Susceptibility To, 5
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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