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anti-IRAK4 antibody :: Rabbit IRAK4 Polyclonal Antibody

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Catalog # MBS9402787
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
Western Blot (WB)
Product Name

IRAK4, Polyclonal Antibody

Also Known As

IRAK4 antibody

Product Synonym Names
IPD1; REN64; IRAK-4; NY-REN-64
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
460
OMIM
606883
3D Structure
ModBase 3D Structure for Q9NWZ3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody detects endogenous level of total IRAK4 antibody.
Purity/Purification
Antibodies were purified by affinity purification using immunogen.
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein of human IRAK4.
Target Name
IRAK4
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-IRAK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IRAK4 antibody
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-IRAK4 antibody
Applications Tested/Suitable for anti-IRAK4 antibody
Western Blot (WB)
Application Notes for anti-IRAK4 antibody
Western blotting: 1:500 - 1:2000

Western Blot (WB) of anti-IRAK4 antibody
Western blot analysis of extracts of various cell lines, using IRAK4 antibody.
anti-IRAK4 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for IRAK4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,674 Da
NCBI Official Full Name
interleukin-1 receptor-associated kinase 4 isoform a
NCBI Official Synonym Full Names
interleukin-1 receptor-associated kinase 4
NCBI Official Symbol
IRAK4  [Similar Products]
NCBI Official Synonym Symbols
IPD1; REN64; IRAK-4; NY-REN-64
  [Similar Products]
NCBI Protein Information
interleukin-1 receptor-associated kinase 4
UniProt Protein Name
Interleukin-1 receptor-associated kinase 4
UniProt Synonym Protein Names
Renal carcinoma antigen NY-REN-64
UniProt Gene Name
IRAK4  [Similar Products]
UniProt Synonym Gene Names
IRAK-4  [Similar Products]
UniProt Entry Name
IRAK4_HUMAN
NCBI Summary for IRAK4
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for IRAK4
IRAK4: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, TKL; EC 2.7.11.1; TKL group; IRAK family

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: extracellular space; cytoplasm; plasma membrane; endosome membrane; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; interleukin-1 receptor binding; magnesium ion binding; ATP binding; protein kinase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; cytokine production; protein amino acid phosphorylation; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor signaling pathway; JNK cascade; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway

Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1; Irak4 Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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