AAI28169
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,142 Da
NCBI Official Full Name
IRGM protein
NCBI Official Synonym Full Names
immunity-related GTPase family, M
NCBI Protein Information
immunity-related GTPase family M protein
UniProt Protein Name
Immunity-related GTPase family M protein
UniProt Synonym Protein Names
Immunity-related GTPase family M protein 1; Interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47 homolog; LRG-47
UniProt Synonym Gene Names
UniProt Entry Name
IRGM_HUMAN
NCBI Summary for IRGM
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010]
UniProt Comments for IRGM
IRGM: Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility. Defects in IRGM are the cause of susceptibility to inflammatory bowel disease type 19 (IBD19). A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Belongs to the interferon-inducible GTPase family.
Protein type: EC 3.6.5.-; Endoplasmic reticulum; Hydrolase
Chromosomal Location of Human Ortholog: 5q33.1
Cellular Component: Golgi membrane; phagocytic vesicle membrane; cell projection; phagocytic cup
Molecular Function: GTP binding; hydrolase activity
Biological Process: autophagy; innate immune response; inflammatory response
Disease: Mycobacterium Tuberculosis, Susceptibility To; Inflammatory Bowel Disease 19
Research Articles on IRGM
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Products associated with anti-IRGM antibody
Pathways associated with anti-IRGM antibody
Diseases associated with anti-IRGM antibody
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