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anti-ITGA4 antibody :: Rabbit ITGA4 / VLA-4 / CD49d Polyclonal Antibody

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Catalog # MBS243684
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

ITGA4 / VLA-4 / CD49d, Polyclonal Antibody

Also Known As

Rabbit Polyclonal to Human ITGA4 / VLA-4 / CD49d

Product Synonym Names
Anti-ITGA4 / VLA-4 / CD49d Antibody (C-Terminus) IHC-plus; ITGA4; 269C wild type; CD49D; IA4; Integrin alpha-4; Integrin alpha 4; Integrin alpha-4 subunit; Integrin alpha-IV; VLA-4; VLA-4 subunit alpha; CD49d antigen; Human ITGA4; VLA-4; CD49d
Product Synonym Gene Name
VLA-4; CD49d[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1032
OMIM
192975
3D Structure
ModBase 3D Structure for P13612
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.02% sodium azide
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
A 13 amino acid peptide from near the carboxy terminus of human Integrin alpha 4.
Immunogen Type
Synthetic peptide
Immunogen
ITGA4 / VLA-4 / CD49d antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human Integrin alpha 4.
Antigen Modification
C-Terminus
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Other Notes
Small volumes of anti-ITGA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ITGA4 antibody
ITGA4 encodes integrin alpha chain 4. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Although alpha 4 is variably cleaved to yield two unlinked chains, this cleavage is unnecessary for integrin assembly and function.
Product Categories/Family for anti-ITGA4 antibody
Applications Tested/Suitable for anti-ITGA4 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-ITGA4 antibody
IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)
Usage: Integrin alpha 4 antibody can be used for the detection of Integrin alpha 4 by Western blot at 0.5-1 ug/ml

Immunohistochemistry (IHC) of anti-ITGA4 antibody
Anti-ITGA4 / Integrin Alpha 4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ITGA4 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-ITGA4 antibody
Western blot of Integrin alpha 4 in Jurkat cell lysate with Integrin alpha 4 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
anti-ITGA4 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ITGA4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,536 Da
NCBI Official Full Name
integrin alpha-4
NCBI Official Synonym Full Names
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
NCBI Official Symbol
ITGA4  [Similar Products]
NCBI Official Synonym Symbols
IA4; CD49D
  [Similar Products]
NCBI Protein Information
integrin alpha-4; 269C wild type; integrin alpha 4; integrin alpha-IV; VLA-4 subunit alpha; integrin alpha-4 subunit; CD49 antigen-like family member D; antigen CD49D, alpha-4 subunit of VLA-4 receptor; very late activation protein 4 receptor, alpha 4 subunit
UniProt Protein Name
Integrin alpha-4
UniProt Synonym Protein Names
CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD_antigen: CD49d
Protein Family
UniProt Gene Name
ITGA4  [Similar Products]
UniProt Synonym Gene Names
CD49D  [Similar Products]
UniProt Entry Name
ITA4_HUMAN
NCBI Summary for ITGA4
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]
UniProt Comments for ITGA4
ITGA4: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Belongs to the integrin alpha chain family.

Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q31.3

Cellular Component: focal adhesion; cell surface; membrane; plasma membrane; intercellular junction; external side of plasma membrane

Molecular Function: protein binding; fibronectin binding; metal ion binding; cell adhesion molecule binding

Biological Process: integrin-mediated signaling pathway; regulation of immune response; extracellular matrix organization and biogenesis; cell-matrix adhesion; heart development; receptor clustering; heterophilic cell adhesion; heterotypic cell-cell adhesion; leukocyte adhesion; B cell differentiation; blood vessel remodeling; leukocyte tethering or rolling; blood coagulation; leukocyte migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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