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anti-JUP antibody :: Rabbit JUP Polyclonal Antibody

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Catalog # MBS2519563
Unit / Price
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

JUP, Polyclonal Antibody

Popular Item
Also Known As

JUP Polyclonal Antibody

Product Synonym Names
DP3; PDGB; PKGB; CTNNG; DPIII; ARVD12
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
745
OMIM
173325
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.3mg/mL (lot specific)
Immunogen
Recombinant protein of human JUP
Calculated Molecular Weight: 82kDa
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-JUP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-JUP antibody
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
Product Categories/Family for anti-JUP antibody
Applications Tested/Suitable for anti-JUP antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-JUP antibody
WB: 1:1000-1:5000
IHC: 1:50-1:200

Western Blot (WB) of anti-JUP antibody
Western Blot analysis of Mouse heart tissue and Hela cell, HUVEC cell and Mouse skin tissue using JUP Polyclonal Antibody at dilution of 1:1150
anti-JUP antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-JUP antibody
Immunohistochemistry of paraffin-embedded Human cervical cancer using JUP Polyclonal Antibody at dilution of 1:50
anti-JUP antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-JUP antibody
Immunohistochemistry of paraffin-embedded Human lung cancer using JUP Polyclonal Antibody at dilution of 1:50
anti-JUP antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for JUP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,745 Da
NCBI Official Full Name
junction plakoglobin
NCBI Official Synonym Full Names
junction plakoglobin
NCBI Official Symbol
NCBI Official Synonym Symbols
DP3; PDGB; PKGB; CTNNG; DPIII; ARVD12
  [Similar Products]
NCBI Protein Information
junction plakoglobin; catenin (cadherin-associated protein), gamma 80kDa; desmoplakin III; desmoplakin-3
UniProt Protein Name
Junction plakoglobin
UniProt Synonym Protein Names
Catenin gamma; Desmoplakin III; Desmoplakin-3
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CTNNG; DP3  [Similar Products]
UniProt Entry Name
PLAK_HUMAN
NCBI Summary for JUP
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]
UniProt Comments for JUP
CTNNG: Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma- catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSC2. Belongs to the beta-catenin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: desmosome; internal side of plasma membrane; focal adhesion; apicolateral plasma membrane; intermediate filament; zonula adherens; catenin complex; intercellular junction; fascia adherens; cytosol; Z disc; actin cytoskeleton; cell-cell adherens junction; cytoskeleton; hemidesmosome; cytoplasm; plasma membrane; nucleus; lateral plasma membrane

Molecular Function: protein binding; signal transducer activity; protein homodimerization activity; structural constituent of cell wall; cadherin binding; transcription coactivator activity; structural molecule activity; protein kinase binding; protein phosphatase binding; alpha-catenin binding; nuclear hormone receptor binding

Biological Process: skin development; intercellular junction assembly and maintenance; cell-cell adhesion; cell migration; positive regulation of protein import into nucleus; cytoskeletal anchoring; protein heterooligomerization; regulation of cell fate specification; detection of mechanical stimulus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; vascular endothelial growth factor receptor signaling pathway; regulation of cell proliferation

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 12; Naxos Disease
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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