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Rabbit karyopherin (importin) beta 1 Polyclonal Antibody

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Catalog # MBS713065
Unit / Price
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  0.05 mL  /  $230 +1 FREE 8GB USB
  0.15 mL  /  $500 +1 FREE 8GB USB
anti-karyopherin (importin) beta 1 antibody
Product Name

karyopherin (importin) beta 1, Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human karyopherin (importin) beta 1 polyclonal Antibody

Product Synonym Names
karyopherin (importin) beta 1; KPNB1; IMB1; IPO1; IPOB; Impnb; MGC2155; MGC2156; MGC2157; NTF97
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS713065 Technical Datasheet
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human,Mouse,Rat; Other species are not tested. Please decide the specificity by homology.
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Immunogen
Human KPNB1
Conjugate
Non-conjugated
Storage Buffer
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1863 / sc-1919 / sc-11367
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-karyopherin (importin) beta 1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-karyopherin (importin) beta 1 antibody
Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.
Applications Tested/Suitable for anti-karyopherin (importin) beta 1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
ELISA:Use at an assay dependent dilution.
WB : 1:200-1:2000
IHC : 1:20-1:200 (Recommender dilutions)
Positive WB detected in: Mouse brain tissue, A2780 cells, HeLa cells, HT-1080 cells, rat brain tissue
Positive IHC detected in: Human colon cancer tissue
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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