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anti-KCND3 antibody :: Rabbit KCND3 Polyclonal Antibody

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Catalog # MBS9126296
Unit / Price
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  0.05 mL  /  $230 +1 FREE 8GB USB
  0.1 mL  /  $305 +1 FREE 8GB USB
  0.2 mL  /  $460 +1 FREE 8GB USB
Product Name

KCND3, Polyclonal Antibody

Full Product Name

KCND3

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 607346
3D Structure
ModBase 3D Structure for Q9UK17
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Species
Human
Immunogen
Recombinant Protein
Other Notes
Small volumes of anti-KCND3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-KCND3 antibody
Applications Tested/Suitable for anti-KCND3 antibody
Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-KCND3 antibody
Western blot analysis of extracts of various cell lines, using KCND3 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-KCND3 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-KCND3 antibody
Immunohistochemistry of paraffin-embedded mouse brain using KCND3 antibody at dilution of 1:100 (40x lens).
anti-KCND3 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for KCND3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
655
NCBI Official Full Name
Potassium voltage-gated channel subfamily D member 3
NCBI Official Synonym Full Names
potassium voltage-gated channel, Shal-related subfamily, member 3
NCBI Official Symbol
KCND3  [Similar Products]
NCBI Official Synonym Symbols
KV4.3; SCA19; SCA22; KCND3L; KCND3S; KSHIVB
  [Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily D member 3; voltage-gated K+ channel; potassium ionic channel Kv4.3; sha1-related potassium channel Kv4.3; voltage-gated potassium channel subunit Kv4.3
UniProt Protein Name
Potassium voltage-gated channel subfamily D member 3
UniProt Synonym Protein Names
Voltage-gated potassium channel subunit Kv4.3
UniProt Gene Name
KCND3  [Similar Products]
UniProt Entry Name
KCND3_HUMAN
NCBI Summary for KCND3
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for KCND3
Kv4.3: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS). Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: voltage-gated potassium channel complex; cell soma; dendrite; plasma membrane; sarcolemma

Molecular Function: protein binding; metal ion binding; delayed rectifier potassium channel activity; A-type (transient outward) potassium channel activity

Biological Process: synaptic transmission; potassium ion transport; protein homooligomerization

Disease: Brugada Syndrome 9; Spinocerebellar Ataxia 19
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-KCND3 antibody
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