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anti-KCNJ5 antibody :: Rabbit KCNJ5 Polyclonal Antibody

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Catalog # MBS540656
Unit / Price
  0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
Western Blot (WB)
Product Name

KCNJ5, Polyclonal Antibody

Also Known As

GIRK4 Antibody Affinity Purified

Product Synonym Names
Cardiac ATP sensitive potassium channel; Cardiac inward rectifier; CIR; G protein activated inward rectifier potassium channel 4; GIRK-4; Heart KATP channel; Inward rectifier K+ channel KIR3.4; IRK-4; KATP-1; KCNJ 5; KIR3.4; Potassium channel antibody
Matching Pairs
Antibody: KCNJ5 (MBS540656)
Positive Control: KCNJ5 (MBS542802)
Antibody/Peptide Pairs
KCNJ5 peptide (MBS543755) is used for blocking the activity of KCNJ5 antibody (MBS540656)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
419
OMIM
600734
3D Structure
ModBase 3D Structure for P48544
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Affinity Purified
Concentration
0.53-0.57 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 350-450 on human GIRK4 protein.
Molecular Function
Potassium
Structure
Belongs to inward rectifier-type potassium channel family
Subcellular Location
Membrane; Multi-pass membrane protein
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-KCNJ5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KCNJ5 antibody
Affinity Purified G protein-activated inward rectifier potassium channel 4 Antibody
Applications Tested/Suitable for anti-KCNJ5 antibody
ELISA (EIA), IMM, Western Blot (WB)
Application Notes for anti-KCNJ5 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:250

Western Blot (WB) of anti-KCNJ5 antibody
anti-KCNJ5 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for KCNJ5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,668 Da
NCBI Official Full Name
G protein-activated inward rectifier potassium channel 4
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily J member 5
NCBI Official Symbol
KCNJ5  [Similar Products]
NCBI Official Synonym Symbols
CIR; GIRK4; KATP1; LQT13; KIR3.4
  [Similar Products]
NCBI Protein Information
G protein-activated inward rectifier potassium channel 4
UniProt Protein Name
G protein-activated inward rectifier potassium channel 4
UniProt Synonym Protein Names
Cardiac inward rectifier; CIR; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; IRK-4; KATP-1; Potassium channel, inwardly rectifying subfamily J member 5
UniProt Gene Name
KCNJ5  [Similar Products]
UniProt Synonym Gene Names
GIRK4; GIRK-4; CIR; IRK-4  [Similar Products]
UniProt Entry Name
KCNJ5_HUMAN
NCBI Summary for KCNJ5
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNJ5
GIRK4: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. Defects in KCNJ5 are the cause of long QT syndrome type 13 (LQT13). It is a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. Defects in KCNJ5 are the cause of familial hyperaldosteronism type 3 (FH3). A form of hyperaldosteronism characterized by hypertension secondary to massive adrenal mineralocorticoid production. Like patients with familial hyperaldosteronism type 1 (glucocorticoid-remediable aldosteronism), patients with FH3 present with childhood hypertension, elevated aldosteronism levels, and high levels of the hybrid steroids 18-oxocortisol and 18-hydroxycortisol. However, hypertension and aldosteronism are not reversed by administration of exogenous glucocorticoids and patients require adrenalectomy to control hypertension. Somatic mutations in KCNJ5 have been found in aldosterone-producing adrenal adenomas and can be responsible for aldosteronism associated with cell autonomous proliferation. These are typically solitary, well circumscribed tumors diagnosed between ages 30 and 70. They come to medical attention due to new or worsening hypertension, often with hypokalemia. KCNJ5 mutations produce increased sodium conductance and cell depolarization, which in adrenal glomerulosa cells produces calcium entry, the signal for aldosterone production and cell proliferation. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: external side of plasma membrane; plasma membrane; T-tubule; voltage-gated potassium channel complex

Molecular Function: G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; protein binding

Biological Process: potassium ion import; potassium ion transport

Disease: Hyperaldosteronism, Familial, Type Iii; Long Qt Syndrome 13
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-KCNJ5 antibody
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