NP_001077008.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Related Accession #
Molecular Weight
Calculated MW: 43kDa Molecular Weight: 387 (382)
NCBI Official Full Name
killer cell immunoglobulin-like receptor 3DS1 isoform 1
NCBI Official Synonym Full Names
killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1
NCBI Official Synonym Symbols
KIR-G1; NKAT10; CD158E2; NKAT-10; KIR-123FM [Similar Products]
NCBI Protein Information
killer cell immunoglobulin-like receptor 3DS1
UniProt Protein Name
Killer cell immunoglobulin-like receptor 3DS1
UniProt Synonym Protein Names
MHC class I NK cell receptor; Natural killer-associated transcript 10; NKAT-10
UniProt Synonym Gene Names
UniProt Entry Name
KI3S1_HUMAN
NCBI Summary for KIR3DS1
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
UniProt Comments for KIR3DS1
KIR3DS1: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Belongs to the immunoglobulin superfamily.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: MHC class I receptor activity
Biological Process: immune response; innate immune response; natural killer cell activation; signal transduction
Research Articles on KIR3DS1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-KIR3DS1 antibody
Pathways associated with anti-KIR3DS1 antibody
Diseases associated with anti-KIR3DS1 antibody
Disease Name |
Pubmed Publications |
Infection Antibodies |
>68 publications with KIR3DS1 and Infection |
Lymphatic Diseases Antibodies |
>8 publications with KIR3DS1 and Lymphatic Diseases |
Hematologic Diseases Antibodies |
>7 publications with KIR3DS1 and Hematologic Diseases |
Lymphoma Antibodies |
>7 publications with KIR3DS1 and Lymphoma |
Nervous System Diseases Antibodies |
>5 publications with KIR3DS1 and Nervous System Diseases |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies |
>3 publications with KIR3DS1 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
Neuroblastoma Antibodies |
>1 publications with KIR3DS1 and Neuroblastoma |
Lymphoma, B-Cell Antibodies |
>1 publications with KIR3DS1 and Lymphoma, B-Cell |
Leukemia-Lymphoma, Adult T-Cell Antibodies |
>1 publications with KIR3DS1 and Leukemia-Lymphoma, Adult T-Cell |
Lymphocytosis Antibodies |
>1 publications with KIR3DS1 and Lymphocytosis |
Organs/Tissues associated with anti-KIR3DS1 antibody
|