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anti-KMO antibody :: Rabbit KMO Polyclonal Antibody

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Catalog # MBS9603346
Unit / Price
  0.1 mL  /  $255 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Product Name

KMO, Polyclonal Antibody

Popular Item
Also Known As

KMO Antibody

Product Synonym Names
dJ317G22.1; kmo; KMO_HUMAN; Kynurenine 3 hydroxylase; Kynurenine 3 monooxygenase (kynurenine 3 hydroxylase); Kynurenine 3 monooxygenase; Kynurenine 3-hydroxylase; Kynurenine 3-monooxygenase; RP1-317G22.1
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
486
3D Structure
ModBase 3D Structure for O15229
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Specificity
KMO antibody detects endogenous levels of KMO.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human KMO.
Subcellular Location
Mitochondrion Outer Membrane
Tissue Specificity
Highest levels in placenta and liver. Detectable in kidney.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-KMO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KMO antibody
Function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable).
Similarity: Transmembrane domains are required for enzymatic activity. Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
Applications Tested/Suitable for anti-KMO antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-KMO antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Western Blot (WB) of anti-KMO antibody
Western blot analysis of extracts from mouse brain, using KMO antibody. Lane 1 was treated with the blocking peptide.
anti-KMO antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-KMO antibody
MBS9603346 at 1/100 staining Mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
anti-KMO antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-KMO antibody
Western blot analysis of extracts of HeLa cells, using KMO antibody.
anti-KMO antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for KMO. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 55.8 kDa
Predicted: 56 kDa
NCBI Official Full Name
kynurenine 3-monooxygenase
NCBI Official Synonym Full Names
kynurenine 3-monooxygenase
NCBI Official Symbol
NCBI Official Synonym Symbols
dJ317G22.1
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NCBI Protein Information
kynurenine 3-monooxygenase
UniProt Protein Name
Kynurenine 3-monooxygenase
UniProt Synonym Protein Names
Kynurenine 3-hydroxylaseUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03018
UniProt Gene Name
NCBI Summary for KMO
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
UniProt Comments for KMO
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-KMO antibody
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