P52294.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Importin subunit alpha-5
NCBI Official Synonym Full Names
karyopherin alpha 1 (importin alpha 5)
NCBI Protein Information
importin subunit alpha-5; SRP1-beta; importin alpha 5; importin-alpha-S1; RAG cohort protein 2; importin subunit alpha-1; nucleoprotein interactor 1; karyopherin subunit alpha-1; recombination activating gene cohort 2
UniProt Protein Name
Importin subunit alpha-5
UniProt Synonym Protein Names
Karyopherin subunit alpha-1; Nucleoprotein interactor 1; NPI-1; RAG cohort protein 2; SRP1-betaImportin subunit alpha-5, N-terminally processed
UniProt Synonym Gene Names
UniProt Entry Name
IMA5_HUMAN
NCBI Summary for KPNA1
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
UniProt Comments for KPNA1
KPNA1: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Belongs to the importin alpha family.
Protein type: Nuclear import; Karyopherin; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 3q21
Cellular Component: nucleoplasm; dendrite; cytoplasm; nuclear pore; cytosol; nucleus
Molecular Function: protein binding; nuclear localization sequence binding; protein transporter activity
Biological Process: viral reproduction; positive regulation of protein import into nucleus; apoptosis; regulation of DNA recombination; cytokine and chemokine mediated signaling pathway; DNA fragmentation during apoptosis; NLS-bearing substrate import into nucleus; viral infectious cycle; cell structure disassembly during apoptosis
Research Articles on KPNA1
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Products associated with anti-KPNA1 antibody
Pathways associated with anti-KPNA1 antibody
Diseases associated with anti-KPNA1 antibody
Organs/Tissues associated with anti-KPNA1 antibody
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