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anti-LMNA antibody :: Rabbit Lamin A/C Polyclonal Antibody

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Catalog # MBS2538800
Unit / Price
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

Lamin A/C (LMNA), Polyclonal Antibody

Popular Item
Full Product Name

Lamin A/C Polyclonal Antibody

Product Synonym Names
LMNA; LMN1; Prelamin-A/C
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
115200
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from human Lamin A/C around the non-phosphorylation site of S392.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-LMNA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-LMNA antibody
Applications Tested/Suitable for anti-LMNA antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-LMNA antibody
WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100, ELISA: 1:5000-1:20000

Western Blot (WB) of anti-LMNA antibody
Western Blot analysis of various cells using Lamin A/C Polyclonal Antibody at dilution of 1:2000.
anti-LMNA antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-LMNA antibody
Immunohistochemistry of paraffin-embedded Human uterus tissue using Lamin A/C Polyclonal Antibody at dilution of 1:200.
anti-LMNA antibody Immunohistochemistry (IHC) (IHC) image
Immunofluorescence (IF) of anti-LMNA antibody
Immunofluorescence analysis of Human liver tissue using Lamin A/C Polyclonal Antibody at dilution of 1:200.
anti-LMNA antibody Immunofluorescence (IF) image
NCBI/Uniprot data below describe general gene information for LMNA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 74
Observed MW: 74+65[Similar Products]
NCBI Official Full Name
lamin isoform A
NCBI Official Synonym Full Names
lamin A/C
NCBI Official Symbol
NCBI Official Synonym Symbols
FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B
  [Similar Products]
NCBI Protein Information
lamin
UniProt Protein Name
Prelamin-A/C
UniProt Synonym Protein Names
Lamin-A/CAlternative name(s):70 kDa lamin; Renal carcinoma antigen NY-REN-32
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
LMNA_HUMAN
NCBI Summary for LMNA
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
UniProt Comments for LMNA
lamin A/C: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. Cleaved by caspase-6 during apoptosis into a 40-45 kDa and a28 kDa fragment.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: cytoplasm; cytosol; intermediate filament; lamin filament; nuclear envelope; nuclear lamina; nuclear matrix; nuclear membrane; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: protein binding; protein phosphatase 1 binding; structural molecule activity

Biological Process: apoptosis; cell structure disassembly during apoptosis; cellular protein metabolic process; establishment and/or maintenance of microtubule cytoskeleton polarity; mitotic cell cycle; mitotic nuclear envelope disassembly; mitotic nuclear envelope reassembly; muscle development; positive regulation of osteoblast differentiation; programmed cell death; regulation of cell migration; response to mechanical stimulus; spermatogenesis; sterol regulatory element binding protein nuclear translocation; unfolded protein response; ventricular cardiac muscle cell development

Disease: Cardiomyopathy, Dilated, 1a; Cardiomyopathy, Dilated, With Hypergonadotropic Hypogonadism; Charcot-marie-tooth Disease, Axonal, Type 2b1; Emery-dreifuss Muscular Dystrophy 2, Autosomal Dominant; Emery-dreifuss Muscular Dystrophy 3, Autosomal Recessive; Heart-hand Syndrome, Slovenian Type; Hutchinson-gilford Progeria Syndrome; Lipodystrophy, Familial Partial, Type 2; Mandibuloacral Dysplasia With Type A Lipodystrophy; Muscular Dystrophy, Congenital, Lmna-related; Muscular Dystrophy, Limb-girdle, Type 1b; Restrictive Dermopathy, Lethal
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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