NP_001014987.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
linker for activation of T-cells family member 1 isoform b
NCBI Official Synonym Full Names
linker for activation of T cells
NCBI Protein Information
linker for activation of T-cells family member 1
UniProt Protein Name
Linker for activation of T-cells family member 1
UniProt Synonym Protein Names
36 kDa phospho-tyrosine adapter protein; pp36; p36-38
UniProt Synonym Gene Names
NCBI Summary for LAT
The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for LAT
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
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Pathways associated with anti-LAT antibody
Diseases associated with anti-LAT antibody
Organs/Tissues associated with anti-LAT antibody
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