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anti-LGR5 antibody :: Rabbit LGR5 Polyclonal Antibody

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Catalog # MBS2524997
Unit / Price
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

LGR5, Polyclonal Antibody

Popular Item
Also Known As

LGR5 Polyclonal Antibody

Product Synonym Names
FEX, HG38, GPR49, GPR67, GRP49
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS2524997 Technical Datasheet
Immunogen Sequence Length
835
OMIM
606667
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human LGR5
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20°C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-LGR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LGR5 antibody
This gene encodes Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicle. Target gene of Wnt signaling.
Product Categories/Family for anti-LGR5 antibody
Applications Tested/Suitable for anti-LGR5 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-LGR5 antibody
IHC: 1:25-1:100

Immunohistochemistry (IHC) of anti-LGR5 antibody
Immunohistochemistry of paraffin-embedded Human brain tissue using LGR5 Polyclonal Antibody at dilution 1:25
anti-LGR5 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for LGR5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
leucine-rich repeat-containing G-protein coupled receptor 5 isoform 3
NCBI Official Synonym Full Names
leucine-rich repeat containing G protein-coupled receptor 5
NCBI Official Symbol
NCBI Official Synonym Symbols
FEX; HG38; GPR49; GPR67; GRP49
  [Similar Products]
NCBI Protein Information
leucine-rich repeat-containing G-protein coupled receptor 5; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; leucine-rich repeat-containing G protein-coupled receptor 5; orphan G protein-coupled receptor HG38
UniProt Protein Name
Leucine-rich repeat-containing G-protein coupled receptor 5
UniProt Synonym Protein Names
G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38
UniProt Gene Name
UniProt Synonym Gene Names
GPR49; GPR67  [Similar Products]
UniProt Entry Name
LGR5_HUMAN
NCBI Summary for LGR5
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
UniProt Comments for LGR5
LGR5: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of cycling, long-lived and multipotent adult stem cell populations. Target gene of Wnt signaling. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Intestinal Lgr5+ stem cells give rise throughout life to proliferation of cells in crypts, which migrate along the crypt-villus axis, differentiating into five main cell types. Wnt signaling plays a crucial role in the proliferation and differentiation of these crypt epithelial cells. Two isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 12q22-q23

Cellular Component: integral to plasma membrane; plasma membrane; trans-Golgi network membrane

Molecular Function: G-protein coupled receptor activity; protein binding; transmembrane receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; inner ear development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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