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anti-LPAR1 antibody :: Rabbit LPAR1 Polyclonal Antibody

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Catalog # MBS2542797
Unit / Price
  0.02 mL  /  $110 +1 FREE 8GB USB
  0.06 mL  /  $150 +1 FREE 8GB USB
  0.12 mL  /  $225 +1 FREE 8GB USB
  0.2 mL  /  $360 +1 FREE 8GB USB
Product Name

LPAR1, Polyclonal Antibody

Popular Item
Full Product Name

LPAR1 Polyclonal Antibody

Product Synonym Names
EDG2; LPA1; VZG1; GPR26; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
U80811 mRNA
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purification
Concentration
1.2mg/ml (lot specific)
Immunogen
Synthetic peptide of human LPAR1
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-22207 / sc-22209
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-LPAR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LPAR1 antibody
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion.
Applications Tested/Suitable for anti-LPAR1 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-LPAR1 antibody
ELISA: 1:2000-5000
IHC: 1:25-100

Immunohistochemistry (IHC) of anti-LPAR1 antibody
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using LPAR1 Polyclonal Antibody at dilution 1:20
anti-LPAR1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-LPAR1 antibody
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using LPAR1 Polyclonal Antibody at dilution 1:20
anti-LPAR1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for LPAR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,346 Da
NCBI Official Full Name
lysophosphatidic acid receptor 1
NCBI Official Synonym Full Names
lysophosphatidic acid receptor 1
NCBI Official Symbol
LPAR1  [Similar Products]
NCBI Official Synonym Symbols
EDG2; LPA1; VZG1; GPR26; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3
  [Similar Products]
NCBI Protein Information
lysophosphatidic acid receptor 1
UniProt Protein Name
Lysophosphatidic acid receptor 1
UniProt Synonym Protein Names
Lysophosphatidic acid receptor Edg-2
UniProt Gene Name
LPAR1  [Similar Products]
UniProt Synonym Gene Names
EDG2; LPA1; LPA receptor 1; LPA-1  [Similar Products]
UniProt Entry Name
LPAR1_HUMAN
NCBI Summary for LPAR1
The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]
UniProt Comments for LPAR1
LPAR1: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 9q31.3

Cellular Component: cell surface; endocytic vesicle; endosome; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding

Biological Process: elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; phospholipase C activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAPKKK cascade; positive regulation of Rho protein signal transduction; positive regulation of stress fiber formation; regulation of cell shape
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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