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anti-LY86 antibody :: Rabbit Lymphocyte antigen 86/MD-1 Polyclonal Antibody

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Catalog # MBS395990
Unit / Price
  0.1 mg  /  $510 +1 FREE 8GB USB
Western Blot/Blotting
Product Name

Lymphocyte antigen 86/MD-1 (LY86), Polyclonal Antibody

Full Product Name

Lymphocyte antigen 86 (IN)/MD-1

Product Synonym Names
MD-1 (IN): Lymphocyte antigen 86
Product Gene Name

anti-LY86 antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Chromosome Location
Chromosome: 6; NC_000006.11 (6588934..6655216). Location: 6p25.1
OMIM
605241
3D Structure
ModBase 3D Structure for O95711
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Immunoaffiinity Purification
Form/Format
Provided as solution in phosphate buffered saline with 0.02% sodium azide
Immunogen
Rabbit polyclonal MD-1 antibody was raised against a 15 amino acid peptide from near the center of human MD-1.
Positive Control
May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression. Highly expressed in B-cells, monocytes and tonsil.5
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Other Notes
Small volumes of anti-LY86 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-LY86 antibody
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD-1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.
Product Categories/Family for anti-LY86 antibody
Polyclonal Antibody; Growth Factors & Receptors
Applications Tested/Suitable for anti-LY86 antibody
Western Blot (WB)
Western Blot/Blotting of anti-LY86 antibody
Western blot analysis of MD-1 in Daudi cell lysate with MD-1 antibody at (A) 1 and (B) 2 g/ml.
anti-LY86 antibody Western Blot/Blotting (WB) image
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NCBI/Uniprot data below describe general gene information for LY86. It may not necessarily be applicable to this product.
NCBI GI #
4758708
NCBI GeneID
9450
NCBI Accession #
NP_004262.1 [Other Products]
NCBI GenBank Nucleotide #
NM_004271.3 [Other Products]
UniProt Primary Accession #
O95711 [Other Products]
UniProt Secondary Accession #
Q9UQC4[Other Products]
UniProt Related Accession #
O95711[Other Products]
Molecular Weight
17.9 kD[Similar Products]
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NCBI Official Full Name
lymphocyte antigen 86
NCBI Official Synonym Full Names
lymphocyte antigen 86
NCBI Official Symbol
LY86  [Similar Products]
NCBI Official Synonym Symbols
MD-1; MMD-1; dJ80N2.1; RP1-80N2.1
  [Similar Products]
NCBI Protein Information
lymphocyte antigen 86; ly-86; protein MD-1; MD-1, RP105-associated
UniProt Protein Name
Lymphocyte antigen 86
UniProt Synonym Protein Names
Protein MD-1
Protein Family
Lymphocyte antigen
UniProt Gene Name
LY86  [Similar Products]
UniProt Synonym Gene Names
MD1; Ly-86  [Similar Products]
UniProt Entry Name
LY86_HUMAN
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UniProt Comments for LY86
Function: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression

By similarity.

Subunit structure: M-shaped tetramer of two CD180-LY86 heterodimers. Ref.6

Subcellular location: Secreted › extracellular space. Note: Associated with CD180 at the cell surface.

Tissue specificity: Highly expressed in B-cells, monocytes and tonsil.

Induction: In monocytes, down-regulated by the cell-wall fraction of Mycobacterium bovis (BCG-CWS).

Sequence caution: The sequence BAA76410.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on LY86
1. MD-1 may be a disease susceptibility gene for adult asthma in a Southern Han population in China.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated withanti-LY86 antibody
 Reference Product  PubMed Publications
 TLR4 antibody  >19 publications with LY86 and TLR4
 CD180 antibody  >10 publications with LY86 and CD180
 CD14 antibody  >9 publications with LY86 and CD14
 LY96 antibody  >8 publications with LY86 and LY96
Pathways associated with anti-LY86 antibody
 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Toll Like Receptor 4 (TLR4) Cascade Pathway antibodies  Toll Like Receptor 4 (TLR4) Cascade Pathway Diagram
 Toll-Like Receptors Cascades Pathway antibodies  Toll-Like Receptors Cascades Pathway Diagram
Diseases associated with anti-LY86 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with LY86 and Inflammation
 Necrosis Antibodies  >3 publications with LY86 and Necrosis
 Cardiovascular Diseases Antibodies  >3 publications with LY86 and Cardiovascular Diseases
 Drug Toxicity Antibodies  >2 publications with LY86 and Drug Toxicity
 Weight Loss Antibodies  >2 publications with LY86 and Weight Loss
 Disease Models, Animal Antibodies  >2 publications with LY86 and Disease Models, Animal
 Pregnancy Complications Antibodies  >1 publications with LY86 and Pregnancy Complications
 Atherosclerosis Antibodies  >1 publications with LY86 and Atherosclerosis
 Fatty Liver Antibodies  >1 publications with LY86 and Fatty Liver
 Kidney Diseases Antibodies  >1 publications with LY86 and Kidney Diseases
Organs/Tissues associated with anti-LY86 antibody
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >6 publications with LY86 and Spleen
 Vascular Antibodies  >2 publications with LY86 and Vascular
 Lymph Node Antibodies  >2 publications with LY86 and Lymph Node
 Placenta Antibodies  >1 publications with LY86 and Placenta
 Intestine Antibodies  >1 publications with LY86 and Intestine
 Pharynx Antibodies  >1 publications with LY86 and Pharynx
 Bone Marrow Antibodies  >1 publications with LY86 and Bone Marrow
 Lung Antibodies  >1 publications with LY86 and Lung
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