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anti-LY86 antibody :: Rabbit Lymphocyte antigen 86/MD-1 Polyclonal Antibody

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Catalog # MBS395990
Unit / Price
  0.1 mg  /  $510 +1 FREE 8GB USB
Western Blot/Blotting
Product Name

Lymphocyte antigen 86/MD-1 (LY86), Polyclonal Antibody

Full Product Name

Lymphocyte antigen 86 (IN)/MD-1

Product Synonym Names
MD-1 (IN): Lymphocyte antigen 86
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_000006.11 (6588934..6655216). Location: 6p25.1
3D Structure
ModBase 3D Structure for O95711
Species Reactivity
Human, Mouse, Rat
Antigen Immunoaffiinity Purification
Provided as solution in phosphate buffered saline with 0.02% sodium azide
Rabbit polyclonal MD-1 antibody was raised against a 15 amino acid peptide from near the center of human MD-1.
Positive Control
May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression. Highly expressed in B-cells, monocytes and tonsil.5
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Other Notes
Small volumes of anti-LY86 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LY86 antibody
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD-1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.
Applications Tested/Suitable for anti-LY86 antibody
Western Blot (WB)

Western Blot/Blotting of anti-LY86 antibody
Western blot analysis of MD-1 in Daudi cell lysate with MD-1 antibody at (A) 1 and (B) 2 g/ml.
anti-LY86 antibody Western Blot/Blotting (WB) image
NCBI/Uniprot data below describe general gene information for LY86. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
lymphocyte antigen 86
NCBI Official Synonym Full Names
lymphocyte antigen 86
NCBI Official Symbol
NCBI Official Synonym Symbols
MD-1; MMD-1; dJ80N2.1; RP1-80N2.1
  [Similar Products]
NCBI Protein Information
lymphocyte antigen 86; ly-86; protein MD-1; MD-1, RP105-associated
UniProt Protein Name
Lymphocyte antigen 86
UniProt Synonym Protein Names
Protein MD-1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
MD1; Ly-86  [Similar Products]
UniProt Entry Name
UniProt Comments for LY86
Function: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression

By similarity.

Subunit structure: M-shaped tetramer of two CD180-LY86 heterodimers. Ref.6

Subcellular location: Secreted › extracellular space. Note: Associated with CD180 at the cell surface.

Tissue specificity: Highly expressed in B-cells, monocytes and tonsil.

Induction: In monocytes, down-regulated by the cell-wall fraction of Mycobacterium bovis (BCG-CWS).

Sequence caution: The sequence BAA76410.1 differs from that shown. Reason: Erroneous initiation.
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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