NP_877439.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,639 Da
NCBI Official Full Name
metastasis-associated in colon cancer protein 1
NCBI Official Synonym Full Names
metastasis associated in colon cancer 1
NCBI Official Synonym Symbols
NCBI Protein Information
metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5; putative binding protein 7a5
UniProt Protein Name
Metastasis-associated in colon cancer protein 1
UniProt Synonym Protein Names
SH3 domain-containing protein 7a5
UniProt Entry Name
MACC1_HUMAN
NCBI Summary for MACC1
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
UniProt Comments for MACC1
MACC1: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.
Chromosomal Location of Human Ortholog: 7p21.1
Cellular Component: cytoplasm; nucleus
Molecular Function: growth factor activity
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of cell division
Research Articles on MACC1
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Products associated with anti-MACC1 antibody
Diseases associated with anti-MACC1 antibody
Organs/Tissues associated with anti-MACC1 antibody
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